Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1995-06-06
1999-03-02
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241931, 42419711, 4241851, 530350, 536 231, 536 237, A61K 39102
Patent
active
058767339
ABSTRACT:
High molecular weight surfaces proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HMW3 and HMW4 have been cloned, expressed and partially sequenced.
REFERENCES:
Barenkamp et al. 1990. Ped. Infect. Dis. 9(5):333-339.
Barenkamp et al., Abstract 983, Pediatric Research, vol. 27.
Caputa et al., J. Clin. Microbiol., 1991, 29(11):2418-2423.
Scheerson et al. 1984. Infect. Immun. 45(3):582-591.
Barenkamp et al. 1992. Infect. Immun. 60(4):1302-1313.
Pediatric Infectious Disease Journal, vol. 9, No. 5, issued May 1990, S.J. Barenkamp et al., "Development of Serum Bactericidal Activity Following Nontypable Haemophilus influenzae Acute Otitis Media", pp. 333-339, see entire document.
Journal of Clinical Microbiology, vol. 29, No. 11, issued Nov. 1991, A.C. Caputa et al., "110 Kilodalton Recombinant Protein which is Immunoreactive with Sera from Humans, Dogs, and Horses with Lyme Borreliosis", pp. 2418-2423, see entire document.
Joint Meeting of the American Pediatric Society and the Society for Pediatric Research, 07-10 May 1990, S.J. Barenkamp, "Cloning and Expression of Genes for Nontypable Haemophilus influenzae (NTHI) High Molecular Weight (HMW) Outer Membrane Proteins which are Targets of Bactericidal Antibody", Abstract 983, Pediatric Research, vol. 27, (4 part 2).
The Journal of Infectious Diseases, vol. 165 (Suppl.), issued Aug. 1992, S.J.Barenkamp, "Outer Membrane Protein and Lipopolysaccharides of Nontypeable Haemophilus influenzae", pp. S181-S184, see entire document.
Infection and Immunity, vol. 60(40, issued Apr. 1992, S.J.Barenkamp et al., Cloning, Expression and DNA Sequence Analysis of Genes Encoding Nontypable Haemophilus influenzae High-Molecular-Weight Surface-Exposed Proteins Related to Filamentous Hemagglutinin of Bordetella pertussis pp. 1302-1313, see entire document.
Infection and Immunity, vol. 56(l), issued Jan. 1988, E.J. Hansen, Immune Enhancement of Pulmonary Clearance on Nontypable Haemophilus influenzae, pp. 182-190, see entire document, especially Figures 3 and 4.
Infection and Immunity, vol. 52(2), issued May 1986, S.J. Barenkamp, "Protection by Serum Antibodies in Experimental Nontypable Haemophilus influenzae Otitis Media", pp. 572-578, see Figures 1 and 2.
Proceedings of the National Academy of Sciences USA, vol. 80, issued Mar. 1983, R.A. Young et al, "Efficient Isolation of Genes by Using Antibody Probes", pp. 1194-1198, see entire document.
Infection and Immunity, vol. 45(3), issued Sep. 1984, R. Schneerson et al, "Serum Antibody Responses of Juvenile and Infant Rhesus Monkeys Injected with Haemophilus influenzae Type b and Pneumococcus Type 6A Capsular Polysaccharide-Protein Conjugates", pp. 582-591, see entire document.
Journal of Molecular Biology, vol. 157, issued 1982, J. Kyte et al, "A Simple Method for Displaying the Hydropathic Character of a Protein", pp. 105-132, see entire document.
Proceedings of the National Academy of Sciences, vol. 78(6), issued Jun. 1981, T.P.Hopp et al, "Prediction of Protein Antigenic Determinants from Amino Acid Sequences", pp. 3824-3828, see entire document.
Pediatr. Infect. Dis. J., 9: 333-339, 1990, Stephen J. Barenkamp and Frank F. Bodor, "Development of Serum Bacterial Activity Following Nontypable Haemophilus influenzae Acute Otitis Media".
Housel James C.
Shaver Jennifer
St. Louis University
Washington University
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