Penem derivatives production and use thereof

Details Penem derivatives production and use thereof Penem derivatives production and use thereof

1991-02-05

1992-05-26

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540310, 514192, C07D49900, A61K 31425

Patent

active

051168324

ABSTRACT:
Novel penem compounds of the formula, ##STR1## wherein R is hydrogen or allyl, and A is an aliphatic 5- or 6-membered heterocyclic group having one or two oxygens in the ring and their pharmaceutically acceptable salts are produced from the compounds of the formula, ##STR2## wherein A is the same as above and respective R.sup.1 and R.sup.2 are protective groups for hydroxyl and carboxyl groups, through several steps. The compounds and their salts are useful as antibacterial agents.

REFERENCES:
patent: 4272437 (1981-06-01), Menard et al.
patent: 4614737 (1986-09-01), Hamanaka

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