Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
1996-03-08
2010-11-02
Marschel, Ardin (Department: 1614)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C435S006120, C436S501000, C536S023100
Reexamination Certificate
active
07825215
ABSTRACT:
Compositions and methods are provided for the nucleic acid mimic determination of nucleic acids. The compositions and methods may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which encode proteins that are implicated in disease states. In accordance with preferred embodiments, mimics are comprised of non-naturally occurring backbones to which are appended modified heterocyclic bases. Such bases preferably have sterically bulky substituents 1, 2, or 3 atoms removed from the sites of attachment to the backbone.
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Christensen Leif
Hansen Henrik Frydenlund
Nielsen Peter E.
ISIS Patent Department
Marschel Ardin
Nielsen Peter E.
Polansky Gregg
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