Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1997-01-17
1999-03-02
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 153, 4241301, 4241411, 4241521, 4241531, 4241541, 4241781, 4241811, 4241831, 600 1, 604 20, A61K 5110, A61K 4300, A61K 3100, A61K 500
Patent
active
058766928
ABSTRACT:
The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of nonlethal doses of total body irradiation, total lymphoid irradiation cell type-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.
REFERENCES:
patent: 4500637 (1985-02-01), Neville et al.
patent: 4998931 (1991-03-01), Slichter et al.
patent: 5178858 (1993-01-01), Reichert et al.
patent: 5187266 (1993-02-01), Farguhar et al.
patent: 5273738 (1993-12-01), Matthews et al.
patent: 5374658 (1994-12-01), Lau
patent: 5514364 (1996-05-01), Ilstad
patent: 5635156 (1997-06-01), Ilstad
Soderling et al., J. Immunol., vol. 135, No. 2, pp. 941-946, Aug. 1985.
Down et al., Blood, vol. 77, No. 3, pp. 661-669, Jan. 1991.
Pierce et al., Transplantation, vol. 48, No. 2, pp. 289-296, Aug. 1989.
Gassmann et al., Transplantation, vol. 41, No. 3, pp. 380-384, Mar. 1986.
Pierce et al., Transplantation, vol. 40, No. 6, pp. 702-707, Dec. 1985.
Nakamura et al., Transplantation, vol. 49, No. 2, pp. 453-458, Feb. 1990.
Antin et al., Blood, vol. 78, No. 8, pp. 2139-2149 as abstracted in Biosis 92:6551, 1991.
Dees Jos,e G.
Hartley Michael G.
The University of Pittsburgh
LandOfFree
Non-lethal methods for conditioning a recipient for bone marrow does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-lethal methods for conditioning a recipient for bone marrow , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-lethal methods for conditioning a recipient for bone marrow will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-419544