RNA interference mediated inhibition of GRB2 associated...

Details RNA interference mediated inhibition of GRB2 associated... RNA interference mediated inhibition of GRB2 associated...

2008-09-02

2010-02-16

Chong, Kimberly (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024310, C536S024100, C435S006120, C435S325000, C435S375000, C514S04400A

Reexamination Certificate

active

07662952

ABSTRACT:
This invention relates to compounds, compositions, and methods useful for modulating GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GRB2 associated binding protein (GAB2) gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GAB2 genes. The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease (leukemia), inflammatory diseases or conditions, allergic diseases or conditions, or proliferative diseases or conditions.

REFERENCES:
patent: 5814620 (1998-09-01), Robinson et al.
patent: 5998203 (1999-12-01), Matulic-Adamic et al.
patent: 5998206 (1999-12-01), Cowsert
patent: 6506559 (2003-01-01), Fire et al.
patent: 2002/0151693 (2002-10-01), Breaker et al.
patent: 2003/0083294 (2003-05-01), Sullenger et al.
patent: 2004/0259247 (2004-12-01), Tuschl et al.
patent: 2005/0020521 (2005-01-01), Rana
patent: 2005/0080246 (2005-04-01), Allerson et al.
patent: 2005/0246794 (2005-11-01), Khvorova et al.
patent: 2359180 (2000-03-01), None
patent: WO-90/14090 (1990-11-01), None
patent: WO-94/01550 (1994-01-01), None
patent: WO-99/32619 (1999-07-01), None
patent: WO-99/49029 (1999-09-01), None
patent: WO-00/44895 (2000-08-01), None
patent: WO-00/44914 (2000-08-01), None
patent: WO-01/36646 (2001-05-01), None
patent: WO-01/96584 (2001-12-01), None
patent: WO-01/96584 (2001-12-01), None
patent: WO 02/22636 (2002-03-01), None
patent: WO-02/44321 (2002-06-01), None
patent: WO-02/44321 (2002-06-01), None
patent: WO-03/064626 (2003-08-01), None
patent: WO-03/064626 (2003-08-01), None
Lynch et al. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO Journal 2002, vol. 21 Nos. 1 &2: 72-82.
Caplen NJ. RNAi as a Gene Therapy Approach. Expert Opinon. Biol. Thera. (2003) vol. 3(4) 575-586. Ashley Publications Ltd.
Parrish et al. Functional Anatomy of a dsRNA trigger: differential requirements for the two trigger strands in RNA interference. Molecular Cell, 2000, vol. 6: 1077-1087.
Braasch et al. Novel Antisense and Peptide Nucleic Acid Strategies for Controlling Gene Expression. Biochemistry 2002, Vo. 41(14): 4503-4510.
Pieken et al. Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes. Science, 1991, vol. 253: pp. 314-317.
Anderson et al. “Bispecific Short Hairpin siRNA Constructs Targeted to CD4, CXCR4, and CCR5 Confer HIV-1 Resistance,”Oligonucleotides13(5):303-312 (2003).
Bass “The Short Answer,” Nature 411:428-429 (2001).
Caplen et al. “RNAi as a Gene Therapy Approach,”Expert Opinion. Biol. Thera. 3(4):575-586 (2003), Ashley Publications Ltd.
Elbashir et al. “Analysis of Gene Function in Somatic Mammalian Cells Using Small Interfering RNAs,”Methods26(2):199-213 (2002).
Elbashir et al. “Duplexes of 21-Nucleotide RNAs Mediate RNA Interference in Cultured Mammalian Cells,”Nature411(6836):494-498 (2001).
Elbashir et al. “Functional Anatomy of siRNAs for Mediating Efficient RNAi inDrosophila melanogasterEmbryo Lysate,”EMBO J. 20(23):6877-6888 (2001).
Elbashir et al. “RNA Interference is Mediated by 21- and 22-Nucleotide RNAs,”Genes Dev. 15(2):188-200 (2001).
Fire et al. “Potent and Specific Genetic Interference by Double-Stranded RNA inCaenorhabditis elegans,”Nature391:806-811 (1998).
Futami et al. “Induction of Apoptosis in HeLa Cells with siRNA Expression Vector Targeted Against Bcl-2,”Nucleic Acids Research Supplement2:251-252 (2002).
Hammond et al. “Post-Transcriptional Gene Silencing by Double-Stranded RNA,”Nature Reviews2:110-119 (2001).
International Search Report mailed on Mar. 18, 2005 for PCT/US03/04909, 2 pages.
International Search Report mailed on Mar. 31, 2005 for PCT/US04/16390, 2 pages.
International Search Report mailed on Oct. 17, 2003 for PCT/US03/05028, 2 pages.
International Search Report mailed on Oct. 17, 2003 for PCT/US03/05346, 1 page.
Jiang “Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits,” Mol. Biol. Of The Cell. 14:858-870 (2003).
Leirdal et al. “Gene Silencing in Mammalian Cells by Preformed Small RNA Duplexes,”Biochemical and Biophysical Research Communications295:744-748 (2002).
Lin et al. “A Novel mRNA-cDNA Interference Phenomenon for Silencing Bcl-2 Expression in Human LNCaP Cells,”Biochemical and Biophysical Research Communications281:639-644 (2001).
Lynch et al. “PKB-Mediated Negative Feedback Tightly Regulates Mitogenic Signaling via Gab2,”EMBO Journal21:72-82 (2002).
Nishida “Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors,” Blood 93(6):1809-1816 (1999).
Olie et al. “Analysis of Ribosyl-Modified, Mixed Backbone Analogs of bcl-2/bc1-xL Antisense Oligonucleotide,”Biochimica et Biophysica Acta1576:101-109 (2002).
Parrish “Functional Anatomy of a dsRNA Trigger: Diferential Requirement for the Two Trigger Strands in RNA Interference,” Mol. Cell. 6:1077-1087 (2000).
Tari “Growth Inhibition of Breast Cancer Cells by Grb2 Downregulation is Correlated with Inactivation of Mitogen-Activated Protein Kinase in EGFR, but Not in ErbB2 cells,” Oncogene 18:1325-1332 (1999).
Tuschl et al. “Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Therapy,”Molecular Interventions295(3):158-167 (2002).
Tuschl et al. “Targeted mRNA Degradation by Double-Stranded RNA In Vitro,”Genes and Development13(24):3191-3197 (1999).
Vickers et al. “Efficient Reduction of Target RNAs by Small Interfering RNa and RNase H-dependent Antisense Agents,” J. Biol. Chem. 278(9):7108-7118 (2003).
Office Action mailed on Oct. 20, 2006 for U.S. Appl. No. 10/923,380, 20 pages.
Office Action mailed on Jul. 3, 2007 for U.S. Appl. No. 10/923,380, 22 pages.
Office Action mailed on Feb. 4, 2008 for U.S. Appl. No. 10/444,853, 37 pages.
Office Action mailed on Jun. 26, 2008 for U.S. Appl. No. 10/923,380, 21 pages.
Office Action mailed on Jul. 1, 2008 for U.S. Appl. No. 11/499,520, 13 pages.
Office Action mailed on Jul. 2, 2008 for U.S. Appl. No. 10/757,803, 26 pages.
Office Action mailed on Oct. 8, 2008 for U.S. Appl. No. 11/499,529, 34 pages.
Office Action mailed on Nov. 14, 2008 for U.S. Appl. No. 11/502,875, 14 pages.
Office Action mailed on Jan. 26, 2009 for U.S. Appl. No. 11/676,124, 15 pages.
Office Action mailed on Feb. 3, 2009 for U.S. Appl. No. 10/693,059, 7 pages.
Office Action mailed on Apr. 8, 2009 for U.S. Appl. No. 11/502,876, 31 pages.
Office Action mailed on Apr. 16, 2009 for U.S. Appl. No. 12/105,010, 24 pages.

Affiliated with

Also associated with

Rating

RNA interference mediated inhibition of GRB2 associated... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with RNA interference mediated inhibition of GRB2 associated..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and RNA interference mediated inhibition of GRB2 associated... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4193977