Transdifferentiation of pancreatic acinar cells

Details Transdifferentiation of pancreatic acinar cells Transdifferentiation of pancreatic acinar cells

2003-01-08

2010-02-16

Audet, Maury (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S326000, C424S001690

Reexamination Certificate

active

07662768

ABSTRACT:
Pancreatic acinar cells contribute to β-cell neogenesis. Hamsters administered pentadecapeptide of INGAP protein demonstrated a 2-fold increase in the number of extra-islet acinar-associated β-cell clusters resulting in a 2.8-fold increase in the overall extra-islet β cell mass as compared to controls. In mammals acinar-to-β-cell differentiation provides an alternate pathway to β-cell neogenesis; INGAP peptide plays a significant role in this process.

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