Process for the preparation of D-(+)-biotin

Details Process for the preparation of D-(+)-biotin Process for the preparation of D-(+)-biotin

1988-01-06

1989-06-06

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49504

Patent

active

048374024

ABSTRACT:
D-(+)-Biotin can be prepared from optically active hydantoins of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in patent claim 1, in a simple, stereospecific manner.
Furthermore bicyclic nitriles of the formula XI ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given represent precious intermediate products and educts of a multitude of possibilities to synthesize optically active D-(+)-biotin.

REFERENCES:
patent: 4468516 (1984-08-01), Volkmann

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