Substrate for Rpn11 enzymatic activity

Details Substrate for Rpn11 enzymatic activity Substrate for Rpn11 enzymatic activity

2006-05-30

2010-06-22

Desai, Anand U (Department: 1656)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C514S002600

Reexamination Certificate

active

07741432

ABSTRACT:
The present application provides peptides that serve as substrates for proteasome enzymatic activity, e.g., the enzymatic activity of Rpn11, a metalloprotease of the 19S regulatory particle. The present application also provides methods and compositions employing the peptide substrates.

REFERENCES:
patent: 5340736 (1994-08-01), Goldberg
patent: 2002/0156012 (2002-10-01), Lyapina et al.
patent: 2003/0153097 (2003-08-01), Deshaies et al.
patent: 2003/0166643 (2003-09-01), McDevitt et al.
patent: 09000263 (1997-01-01), None
patent: WO-98/10779 (1998-03-01), None
patent: WO-99/01567 (1999-01-01), None
patent: WO-02/055536 (2002-07-01), None
Verma et al., “Role of Rpn11 Metalloprotease in Deubiquitination and Degradation by the 26S Proteasome”, Science 298: 611-615 (2002).
Guterman et al., “Complementary Roles for Rpn11 and Ubp6 in Deubiquitination and Proteolysis by the Proteasome,” The Journal of Biological Chemistry, 279(3):1729-1738 (2004).
Lacombe et al., Further characterization of the putative human isopeptidase T catalytic site,: FEBS Letters, 531(3):469-474 (2002).
McCullough et al., “AMSH is an endosome-associated ubiquitin isopeptidase,” The Journal of Cell Biology, 166(4):487-492 (2004).
Altschul et al., J. Mol. Biol. 215:403-410 (1990).
Altschul et al., Nuc. Acids Res. 25:3389-3402 (1997).
Carillo et al., SIAM J. Applied Math 48:1073-1082 (1988).
Ciechanover et al., Trends in Cell Biol. 14(3):103-106 (2004).
Ciechanover, Cell 79:13-21 (1994).
Cohen, Science 267:959-960 (1995).
Collins, T. Lab. Invest. 68:499-508 (1993).
Devereux et al., Nucleic Acids Research 12(1):387-395 (1984).
Eytan et al., JBC 268(7):4668-4674 (1993).
Garrett et al., J. Clin. Invest. 111:1771-1782 (2003).
Gonzales et al., Arch Med. Res. 28, Spec. No. 139-140 (1997).
Hardy et al., Trans. Genet. 8:55-61 (1992).
Harris et al., J. Bone Miner. Res. 9(6):855-863 (1994).
Hilvert, Chem.-Biol. 201-203 (1994).
Kojima et al., Fed. Eur. Biochem. Soc. 304:57-60 (1992).
Kumatori et al., Proc. Natl. Acad. Sci. USA 87:7071-7075 (1990).
Liu et al., Proc. Natl. Acad. Sci. USA 6584-6588 (1994).
Miranda et al., Proc. Natl. Acad. Sci, USA 1181-1186 (1999).
Muir et al., Proc. Natl. Acad. Sci USA 6705-6710 (1998).
Palombella et al., Cell 78:773-785 (1994).
Paugam et al., Trends Parasitol. 19(2):55-59 (2003).
Qureshi et al., J. Immuno. 171:1515-1525 (2003).
Thanos et al., Cell 80:529-532 (1995).
Traenckner et al., EMBO J. 13:5433-5441 (1994).
Verma et al., Mol. Biol. Cell 11:3425-3439 (2000).
Verma et al., Science 306:117-120 (2004).
Wallace, Curr. Opin. Biotechnol. 403-410 (1995).
Yao et al., Nature 419:403-407 (2002).

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