Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2005-05-20
2010-06-29
Ramirez, Delia M (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S193000, C435S015000, C435S006120, C435S320100, C435S252300, C435S325000, C435S069100, C530S350000, C536S023200
Reexamination Certificate
active
07745188
ABSTRACT:
The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other Y-family polymerases, methods of generating other chimeric Y-family polymerases, methods of amplifying ancient or damaged DNA, and methods of incorporating fluorescent or modified nucleotides into a DNA molecule.
REFERENCES:
patent: 2005/0196392 (2005-09-01), Andersen
patent: 2006/0177867 (2006-08-01), Evans et al.
Branden et al., Introduction to Protein Structure, Garland Publishing Inc., New York, p. 247, 1991.
Witkowski et al., Biochemistry 38:11643-11650, 1999.
Seffernick et al., J. Bacteriol. 183(8):2405-2410, 2001.
Barnes et al., “PCR amplification of up to 35-kb DNA with high fidelity and high yield from λ bacteriophage templates,”Proc. Natl. Acad. Sci. 91:2216-2220, Mar. 1994.
Bebenek and Kunkel, “Family growth: the eukaryotic DNA polymerase revolution,”CMLS, Cell, Mol. Life Sci. 59:54-57, 2002.
Boudsocq et al., “Investigating the role of the little finger domain of Y-family DNA polymerases in low-fidelity synthesis and translesion replication,”JBC Papers in Press, Manuscript M405249200, May 21, 2004.
Boudsocq et al., “Sulfolobus solfataricusP2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic polη,”Nucleic Acids Research29(22):4607-4616, 2001.
Friedberg et al., “Error-Prone DNA Polymerases: Novel Structures and the Benefits of Infidelity,”Cell107:9-12, Oct. 5, 2001.
Friedberg et al., “Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations,”Science296:1627-1630, May 31, 2002.
Goodman and Tippin, “Sloppier copier DNA polymerases involved in genome repair,”Curr. Opin. in Genetics and Development10:162-168, 2000.
Goodman and Tippin, “The Expanding Polymerase Universe,”Molecular Cell Biology1:101-109, Nov. 2000.
Grúz et al., “Processing of DNA lesions by archaeal DNA polymerases fromSulfolobus solfataricus,” Nucleic Acids Research31(14):4024-4030, 2003.
Johnson et al., “Deoxynucleotide Triphosphate Binding Mode Conserved in Y Family DNA Polymerases,”Molecular and Cellular Biology23(8):3008-3012, Apr. 2003.
Kokoska et al., “Low Fidelity DNA Synthesis by a Y Family DNA Polymerase Due to Misalignment in the Active Site,”J. Biological Chemistry277(22):19633-19638, 2002.
Kulaeva et al., “Indentification of a DinB / UmuC homolog in the archeonSulfolobus solfataricus,” Mutation Research357:245-253, 1996.
Kusunoki et al., “Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts,”BMC Pharmacology4:2.
Ling et al., “Crystal Structure of a Y-Family DNA Polymerase in Action: A Mechanism for Error-Prone and Lesion-Bypass Replication,”Cell107:91-102, Oct. 5, 2001.
Ling et al., Snapshots of Replication through an Abasic Lesion: Structural Basis for Base Substitutions and Frameshifts,Molecular Cell13:751-762, Mar. 12, 2004.
Masutani et al., “TheXPV(xeroderma pigmentosum variant) gene encodes human DNA polyermase η,”Nature399:700-704, Jun. 17, 1999.
McDonald et al., “Novel thermostable Y-family polymerases: applications for the PCR amplification of damaged or ancient DNAs,”Nature Biotechnology, Letter, Jul. 15, 2005.
McKenzie et al., “SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification,”Molecular Cell7:571-579 , Mar. 2001.
Ohmori et al., “The Y-Family of DNA Polymerases,”Molecular Cell8:7-8, Jul. 2001.
Pavlov et al., “Recent developments in the optimization of thermostable DNA polymerases for efficient applications,”Trends in Biotechnology22(5):253-260, May 2004.
Rossi et al., “Extremophiles 2002,”J. Bacteriology185(13):3683-3689, Jul. 2003.
She et al., “The complete genome of the crenarcheonSulfolobus solfataricusP2,”Cell Biology98(14):7835-7840, Jul. 3, 2001.
Tompkins et al., Error-Prone Polymerase, DNA Polymerase IV, is Responsible for Transient Hypermutation during Adaptive Mutation inEscherichia coli, J. Bacteriology185(11):3469-3472, Jun. 2003.
Wang et al., “A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro,”Nucleic Acids Research32(3):1197-1207, 2004.
Yang, “Damage repair DNA polymerase Y,”Current Opinion in Structural Biology13:23-30, 2003.
Yang et al., A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro.
Yeiser et al., “SOS-induced DNA polymerases enhance long-term survival and evolutionary fitness,”PNAS99(13):8737-8741, Jun. 25, 2002.
McDonald John P.
Woodgate Roger
Yang Wei
Klarquist & Sparkman, LLP
Ramirez Delia M
The United States of America as represented by the Secretary of
LandOfFree
Thermostable Y-family polymerases and chimeras does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thermostable Y-family polymerases and chimeras, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thermostable Y-family polymerases and chimeras will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4183826