Substituted thieno[3,2-D]pyrimidines as non-basic melanin...

Details Substituted thieno[3,2-D]pyrimidines as non-basic melanin... Substituted thieno[3,2-D]pyrimidines as non-basic melanin...

2006-10-25

2010-06-29

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S278000

Reexamination Certificate

active

07745447

ABSTRACT:
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

REFERENCES:
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Ulven, T. et al., “6-Acylamino-2-aminoquinolines as Potent Melanin-Concentrating Hormone 1 Receptor Antagonists. Identification, Structure-Activity Relationship, and Investigation of Binding Mode”, J. Med. Chem., vol. 48, pp. 5684-5697 (2005).
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