Use of L-Carnitine as stabilizing agent of proteins

Details Use of L-Carnitine as stabilizing agent of proteins Use of L-Carnitine as stabilizing agent of proteins

2000-12-15

2010-11-16

Fetterolf, Brandon J (Department: 1642)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07833977

ABSTRACT:
The present invention relates to the technical field of stabilizing proteins, in particular to the therapeutic aspects of protein stabilization. L-carnitine is a useful agent for stabilizing proteins, and in a particularly favourable aspect in proteins used in the medical field. In a preferred aspect, L-carnitine is used for protecting chaperone activity, and in the medical field for preserving the activity of altered chaperone proteins. In connection with this invention L-carnitine is used for the preparation of a medicament for the treatment of diseases due to altered chaperone proteins, such as eye diseases, in particular cataract.

REFERENCES:
patent: 5037851 (1991-08-01), Cavazza
patent: 2003/0068309 (2003-04-01), De Simone
patent: 2004/0058015 (2004-03-01), Tao
patent: 2004/0120967 (2004-06-01), Calvani
patent: 2004/0142879 (2004-07-01), Calvani
patent: 2005/0118153 (2005-06-01), Simone
patent: 2005/0163873 (2005-07-01), Ritch
patent: 2005/0186196 (2005-08-01), De Simone
patent: 2005/0197280 (2005-09-01), De Simone
patent: 2006/0004095 (2006-01-01), Calvani et al.
patent: 2006/0241058 (2006-10-01), Amato et al.
Peluso et al. (J. Cellular Biochemistry 2000; 80: 1-10).
Strauss et al. (J. Mol. Cell Cardiol. 1998; 30: 2319-2325).
Swamy-Mruthinti et al. (Exp. Eye. Res. 1999; 69: 109-115).
Cobb et al. (Biochemistry 2002; 41: 483-490).
Horwitz (Proc. Natl. Acad. Sci. 1992; 89: 10449-10453).
Snoeckx et al. (Physiological Reviews 2001; 81: 1461-2325).
Oimomi et al. (Exp. Eye. Res. 1988; 46: 415-420).
Malina et al. (BMC Opthalmology 2002; 2; 1).
Swamy-Mruthinti et al. (Exp. Eye. Res. 1999; 69: 109-115).
Swamy-Mruthinti et al. (Exp. Eye. Res. 1999; 69: 109-115).
Horwitz (PNAS 1992; 89: 10449-10453).
Swamy-Mruthinti et al, “Inhibition of glycation and glycation mediated changes by L-carnitine in diabetic rat lenses”, FASEB Journal, vol, 14, No. 4, Mar. 15, 2000, p. A504.
Peluso et al, “Carnitine: An Osmolyte That Plays a Metabolic Role”, Journal of Cellular Biochemistry, vol. 80, No. 1, 2000, pp. 1-10.
Swamy-Mruthinti et al, Acetyl-L-Carnitine Decreases Glycation of Lens Proteins: in vitro Studies, Experimental Eye Research, vol. 69, No. 1, Jul. 1999, pp. 1009-1115.

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