Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-09-20
2010-10-12
Olson, Eric S (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S501000, C548S108000, C548S109000, C548S305100, C556S138000
Reexamination Certificate
active
07812042
ABSTRACT:
Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B12for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.
REFERENCES:
patent: 7709460 (2010-05-01), McCaddon
patent: WO02/087593 (2002-11-01), None
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Merriam-Webster's Collegiate Dictionary, Tenth Edition, published 1998 by Merriam-Webster, incorporated, p. 924.
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Suarez-Moriera et al., “A simple, convenient method to synthesize cobalamins: synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin” Dalton Transcations (2006) pp. 5269-5277.
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McCaddon et al., “Co-administration of N-acetylcysteine, vitamin B12 and folate in cognitively impaired hyperhomocysteinaemic patients” International Journal of Geriatric Psychiatry (2005) vol. 20, pp. 998-1000.
Poster, Glutathionylcobalamin and N-Acetyl-L-Cysteinylcobalamin Protect Endothelial Cells from Homocysteine-Induced Oxidant Stress and Increase Intracellular Glutathione, Birch et al., University of Chester and Kent State University—Jun. 2007 Saarbrüecken, Germany.
Birch Catherine Stephanie
Brasch Nicola E.
Williams John Henry Howatson
Hudak, Shunk & Farine Co. LPA
Kent State University
Olson Eric S
University of Chester
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