Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1996-12-20
1999-03-02
Prebilic, Paul B.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 16, 606 76, A61F 202
Patent
active
058764461
ABSTRACT:
Medical devices, most particularly prosthesis, are defined having at least one porous tissue-mating surface. The tissue-mating surface of the device includes therein a biodegradable carrier, such as a biodegradable polymer. The pores or intersticial spaces of the tissue-mating surface of the device are impregnated with the biodegradable polymer. The prosthesis of the present invention provides for enhanced rigid fixation, as pores at the surface of said device provide for bony ingrowth as the biodegradable carrier, i.e., polymer, degrades. Methods for preparing said prosthesis are described. Methods for delivering a pharmacologically active substance by including a pharmacologically active substance in the biodegradable carrier (e.g., polymer) are also disclosed.
REFERENCES:
patent: 4279249 (1981-07-01), Vert et al.
patent: 4563489 (1986-01-01), Urist
patent: 5098779 (1992-03-01), Kronzler et al.
patent: 5250584 (1993-10-01), Ikada et al.
patent: 5258029 (1993-11-01), Chu et al.
patent: 5263986 (1993-11-01), Noiles et al.
patent: 5281419 (1994-01-01), Tuan et al.
patent: 5522895 (1996-06-01), Mikos
Albrektsson and Hansson, "An Ultrastructural Characterization of the Interface Between Bone and Sputtered Titanium or Stainless Steel Surfaces," Biomaterials, 7:201-205, 1986.
Aldinger et al., "Bone Morphogenetic Protein: A Review," International Orthop. (SICOT), 15:169-177, 1991.
Bobyn, et al., "The Optimum Pore Size for the Fixation of Porous-Surfaced Metal Implants by the Ingrowth of Bone," Clinical Orthopaedics and Related Research, 150:263-270, 1980.
Buser et al., "Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs," Journal of Biomedical Materials Research, 25:889-902.
Cameron et al., "The Rate of Bone Ingrowth into Porous Meal," J. Biomed. Mater. Res., 10:295-302, 1976.
Collier et al., "Bone Ingrowth into Dynamically Loaded Porous-Coated Intramedullary Nails," J. Biomed. Mater. Res. Symposium, 10(7):485-492.
Collier et al., "Macroscopic and Microscopic Evidence of Prosthetic Fixation with Porous-Coated Materials," Clinical Orthopaedics and Related Research, 235:173-180, 1988.
Cook et al., "Interface Mechanics and Bone Growth into Porous Co-Cr-Mo Alloy Implants," Clinical Orthopaedics and Related Research, 193:271-280.
D'Allessandro, J.S., et al., "Purification, Characterization, and Activity of Recombinant Human BMP-5," Journal of Cellular Biochemistry, Supplement 15F;166, 1991.
Ferguson et al., "Bovine Bone Morphogenetic Protein (bBMP) Fraction-induced Repair of Craniotomy Defects in the Rhesus Monkey (Macaca speciosa)," Clinical Orthopaedics and Related Research, 219:251-258, 1987.
Hulbert et al., "Attachment of Prostheses to the Musculoskeletal System by Tissue Ingrowth and Mechanical Interlocking," J. Biomed. Mater. Res., 4:1-12, 1973.
Jansen et al., "Histologic evaluation of the osseous adaptation to titanium and hydroxyapatite-coated titanium implants," Journal of Biomedical Materials Research, 25:973-989, 1991.
Lindholm et al., "Bovine Bone Morphogenetic Protein (bBMP) Induced Repair of Skull Trephine Defects in Sheep," Clinical Orthopaedics and Related Research, 227:265-268, 1988.
Miller et al., "The Induction of Bone by an Osteogenic Protein and the Conduction of Bone by Porous Hydroxyapatite: A Laboratory Study in the Rabbit," Plastic and Reconstructive Surgery, 87(1):87-95, 1991.
Mizutani and Urist, "The Nature of Bone Morphogenetic Protein (BMP) Fractions Derived from Bovine Bone Matrix Gelatin," Clinical Orthopaedics and Related Research, 171:213-223,1982.
Ohgushi, et al., "Bone formation process in porous calcium carbonate and hydroxyapatite," Journal of Biomedical Materials Research, 26:885-895, 1992.
Sato et al., "Induced Regeneration of Calvaria by Bone Morphogenetic Protein (BMP) in Dogs," Clinical Orthopaedics and Related Research, 197:301-311, 1985.
Syftestad and Urist, "Bone Aging," Clinical Orthopaedics and Related Research, 162:288-297, 1982.
Takagi and Urist, "The Reaction of the Dura To Bone Morphogenetic Protein (BMP) in Repair of Skull Defects," Ann. Surg., 196(1):100-109, 1982.
Urist et al., "Osteogenetic Competence," Clinical Orthopaedics and Related Research, 64:194-220, 1969.
Wlodarski and Reddi, "Importance of Skeletal Muscle Environment for Ectopic Bone Induction in Mice," Folia Biol., 34:425-434, 1986.
Athanasiou et al., "Biodegradable Carriers of GF-.beta. in Rabbit Osteochondral Defects," 39th Annual Meeting, Orthopaedic Research Society, San Francisco, CA, Feb. 15-18, 1993.
Lind et al., "Transforming Growth Factor-.beta. Enhances Fracture Healing in Rabbit Tibiae," 39th Annual Meeting, Orthopaedic Research Society, San Francisco, CA, Feb. 15-18, 1993.
Lee et al., "Healing of Large Segmental Defects in Rat Femurs is Aided by RhBMP-2 Matrix," J. Biomedical Materials Research, 28:1149-1156, 1994.
Agrawal C. Mauli
Schenck Robert C.
Board of Regents , The University of Texas System
Prebilic Paul B.
LandOfFree
Porous prosthesis with biodegradable material impregnated inters does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Porous prosthesis with biodegradable material impregnated inters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Porous prosthesis with biodegradable material impregnated inters will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-417883