Methods and compositions for predicting drug responses

Details Methods and compositions for predicting drug responses Methods and compositions for predicting drug responses

2007-03-16

2010-11-09

Sitton, Jehanne S (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C536S023100, C536S024300

Reexamination Certificate

active

07829282

ABSTRACT:
The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.

REFERENCES:
patent: 5547835 (1996-08-01), Koster
patent: 6043031 (2000-03-01), Koster et al.
patent: 2006/0166239 (2006-07-01), Chen et al.
patent: WO 95/34679 (1995-12-01), None
patent: WO 2005/030039 (2005-04-01), None
patent: WO 2005/040367 (2005-05-01), None
Lucentini (The Scientist; 2004, vol. 24, p. 20).
Hegele (Arterioscler. Thromb. Vasc. Biol.; 2002, vol. 22, pp. 1056-1061).
Wu et al; Pharmacogenomics, vol. 9, pp. 1-9, 2008.
NCBI Accession No. AY587020, Rieder et al., (May 14, 2004).
Internet website, http://pga.gs.washington.edu/data/vkorc1/, posted to the internet on Mar. 31, 2004 (8 pages).
Rieder et al., “Effect of VKORC1 Haplotypes on Transcriptional Regulation and Warfarin Dose,”New England Journal of Medicine352:2285-2293 (2005).
Wadelius et al., “Common VKORC1 and GGCX Plymorphisms Associated with Warfarin Dose,”Pharmacogenomics Journal5:262-270 (2005).
Geisen et al., “VKORC1 Haplotypes and Their Impact on the Inter-individual and Inter-ethnical Variability of Oral Anticoagulation,”Thrombosis and Haemostasis94:773-770 (2005).
Harrington et al., “Pharmacodynamic Resistance to Warfarin Associated with a Val66Met Substitution in Vitamin K Epoxide Reductase Complex Subunit 1,”Thrombosis and Haemostastis93:23-26 (2005).
Devlin and Risch, 29(2):311-22 (1995).
Fang et al.,Arch Intern Med164:55-60 (2004).
Gage et al.,Stroke31:822-7 (2000).
Higashi et al.,Jama287:1690-8 (2002).
Rost et al.,Nature427:537-41 (2004).
Gate et al.,Thromb Haemost91:87-94 (2004).
Suttie,Adv Exp Med Biol214:3-16 (1987).
Li et al.,Nature427:541-4 (2004).
Fasco et al.,Biochemistry22:5655-60 (1983).
Lesko et al.,Nat Rev Drug Discov3:763-9 (2004).
Aithal et al.,Lancet353:717-9 (1999).
Rettie et al.,Epilepsy Res35:253-5 (1999).
Blann et al.,Br J Haematol107:207-9 (1999).
Gan et al.,Int J Hematol78:84-6 (2003).
Yu et al., Qjm 89:127-35 (1996).
Chenhsu et al.,Ann Pharmacother34:1395-401 (2000).
Absher et al.,Ann Pharmacother36:1512-7 (2002).
Przeworski et al.,Trends Genet16:296-302 (2000).
Crawford et al.,Am J Hum Genet74:610-22 (2004).
Drysdale et al.,Proc Natl Acad Sci USA97:10483-8 (2000).
Durrin et al., “Vitamin D Receptor 3'-untranslated Region Polymorphisms: Lack of Effect on mRNA Stability,”Biochim Biophys Acta1453:311-20 (1999).
Carter et al., “Prothrombin G20210A is a Bifunctional Gene Polymorphism,”Thromb Haemost87:846-53 (2002).
D'Andrea Giovanna et al., “A Polymorphism in the VKORC1 Gene is Associated with an Interindividual Variability in the Dose-Anticoagulant Effect in Warfarin,”Blood105(2):64, 2005.
Rost et al., “Mutations in VKORC1 Cause Warfarin Resistance and Multiple Coagulation Factor Deficienty Tupe 2,”Nature427(6974):537-41 (2004).
Alignment for Genbank Accession No. AC135050 (Feb. 2003).
Alignment for Genbank Accession No. AY58020 (May 2004).
Toomajian et al.,Genetics161:1609-1623 (2002).
ss21323934 (dbSNP database assay ID for rs9934438 (Mar. 19, 2004).
ss13773513 (dbSNP database assay ID for rs9934438 (Nov. 5, 2003).
ss19348150 (dbSNP database assay ID for rs9934438 (Feb. 20, 2004).
Ss24683640 (dbSNP database assay ID for rs9934438 (Aug. 21, 2004).

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