Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2004-11-17
2010-06-08
Leith, Patricia (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C424S756000
Reexamination Certificate
active
07731993
ABSTRACT:
An improved composition for treatment of ulcer-type skin conditions. The composition is primarily characterized by a combination of nitroglycerin and arginine. Other embodiments comprise emollient cream, mineral oil, tumeric powder, folic acid, vitamin B12, and zinc citrate. The composition is particulary effective in improving blood flow in the underlying capillary bed about the wound, improving nerve growth about the wound, increasing circulation, and having a standardized and more predictable therapeutic characteristic.
REFERENCES:
patent: 4226858 (1980-10-01), Pfirrmann et al.
patent: 4393066 (1983-07-01), Garrett et al.
patent: 4432975 (1984-02-01), Libby
patent: 5260066 (1993-11-01), Wood et al.
patent: 5401504 (1995-03-01), Das et al.
patent: 5543430 (1996-08-01), Kaesemeyer
patent: 5672336 (1997-09-01), Sharma
patent: 5693676 (1997-12-01), Gorfine
patent: 5733535 (1998-03-01), Hollingshead et al.
patent: 5789439 (1998-08-01), Hosono et al.
patent: 6133320 (2000-10-01), Yallampalli et al.
patent: 6194455 (2001-02-01), Wharton
patent: 6287601 (2001-09-01), Russell
patent: 6376553 (2002-04-01), Mendel et al.
patent: 6436446 (2002-08-01), Forusz et al.
patent: 6569840 (2003-05-01), Yamashina et al.
patent: 2002/0146463 (2002-10-01), Clayton
patent: 2003/0104033 (2003-06-01), Lai et al.
patent: 2005/0075391 (2005-04-01), Gorfine
patent: 2005/0123632 (2005-06-01), Chen et al.
patent: 2005/0201970 (2005-09-01), Hu
patent: 004240329 (1994-06-01), None
Biswas et al., “Plant Medicines of Indian Origin for Wound Healing Activity: a Review,” Lower Extremity Wounds; vol. 2 No. 1, pp. 25-39 (2003).
Goh et al., “Allergic contact dermatitis toCurcuma longa(turmeric),” Contact Dermatitis; vol. 17 No. 3, p. 186 (Sep. 1987).
J. Graf, “Herbal Anti-Inflammatory Agents for Skin Disease,” Skin Therapy Letter; vol. 5 No. 4, pp. 3-6 (2002).
Perez-Arriaga et al., “Cytotoxic effect of curcumin on Giardia lamblia trophozoites,” Acta Tropica; Vol. 98 No. 2, pp. 152-161 (2006).
Mani et al., “Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing,” BioFactors; vol. 16 No. 1-2, pp. 29-43 (2002).
Gopinath et al., “Dermal wound healing processes with curcumin incorporated collagen films,” Biomaterials; vol. 25 No. 10, pp. 1911-1917 (May 2004).
Joshi et al., “Early Human Safety Study of Turmeric Oil (Curcuma longaOil) Administered Orally in Healthy Volunteers,” Journal of the Association of Physicians of India; vol. 51, pp. 1055-1060 (Nov. 2003).
Jagetia et al., “Role of Curcumin, a Naturally Occurring Phenolic Compound of Turmeric in Accelerating the Repair of Excision Wound, in Mice Whole-Body Exposed to Various Doses of gamma-Radiation,” Journal of Surgical Research; vol. 120, pp. 127-138 (2004).
Maheshwari et al., “Multiple biological activities of curcumin: A short review,” Life Sciences; vol. 78, pp. 2081-2087 (2006).
Sidhu et al., “Enhancement of wound healing by curcumin in animals,” Wound Repair and Regeneration; vol. 6 Issue 2, pp. 167-177 (Mar. 1998).
Hanna et al., “Infrapopliteal Transcatheter Interventions for Limb Salvage in Diabetic Patients: Importance of Aggressive Interventional Approach and Role of Transcutaneous Oximetry,” Journal of the American College of Cardiology; vol. 30 No. 3, pp. 664-669 (Sep. 1997).
Kim et al., “Effect of a Nitroglycerin Patch on Perfusion to the Foot in Healthy Subjects,” Journal of the American Podiatric Medical Association; vol. 96 No. 4, pp. 318-322 (Jul./Aug. 2006).
Satoskar et al., “Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation,” International Journal of Clinical Pharmacology, Therapy and Toxicology; vol. 24 No. 12, pp. 651-654 (1986).
Kundu et al., “Turmeric (Curcuma longa) Rhizome Paste and Honey Show Similar Wound Healing Potential: A Preclinical Study in Rabbits,” Lower Extremity Wounds; vol. 4 No. 4, pp. 205-213 (2005).
Apisariyakul et al., “Antifungal activity of turmeric oil extracted fromCurcuma longa(Zingiberaceae),” Journal of Ethnopharmacology; vol. 49, pp. 163-169 (1995).
Sharma et al., “Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance,” Clinical Cancer Research; vol. 10, pp. 6847-6854 (Oct. 15, 2004).
Davis et al., “Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage,” American Journal of Physiology—Regulatory, Integrative, and Comparative Physiology (Mar. 1, 2007).
Jagetia et al., “‘Spicing Up’ of the Immune System by Curcumin,” Journal of Clinical Immunology; vol. 27 No. 1, pp. 19-35 (Jan. 2007).
Kuttan et al., “Turmeric and Curcumin as Topical Agents in Cancer Therapy,” Tomori; vol. 73, pp. 29-31 (1987).
Cheng et al., “Phase I Clinical Trial of Curcumin, a Chemopreventive Agent, in Patients with High-risk or Pre-malignant Lesions,” Anticancer Research; vol. 21, pp. 2895-2900 (2000).
Liddle et al., “Contact Urticaria from Curcumin,” Dermatitis; vol. 17 No. 4, pp. 196-197 (Dec. 2006).
O'Mahony et al., “Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori,” World Journal of Gastroenterology; vol. 11 No. 47, pp. 7499-7507 (2005).
Negi et al., “Antibacterial Activity of Turmeric Oil: A Byproduct of Curcumin Manufacture,” Journal of Agricultural and Food Chemistry; vol. 47, pp. 4297-4300 (1999).
Tan at al., “Randomized clinical trial of 0.2 percent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy,” British Journal of Surgery; vol. 93, pp. 1464-1468 (2006).
Jones et al., “Treatment of Pressure Ulcers With Nitropaste,” Journal of the American Geriatrics Society; vol. 45 No. 7, p. 895 (Jul. 1997).
Romanelli et al., “The effect of topical nitroglycerin on transcutaneous oxygen,” British Journal of Dermatology; vol. 124, pp. 354-357 (1991).
Juhasz et al., “Nitroglycerin-induced headaches,” Orvosi Hetilap; vol. 145 Part 46, pp. 2323-2328 (Nov. 14, 2004). [abstract only included herewith].
Patti et al., “Efficacy of topical use of 0.2% glyceryl trinitrate in reducing post-haemorrhoidectomy pain and improving wound healing,” Chirurgia Italiana; vol. 57 No. 1, pp. 77-85 (2005).
Shoskes et al., “Beneficial Effects of the Bioflavonoids Curcumin and Quercetin on Early Function in Cadaveric Renal Transplantation: A Randomized Placebo Controlled Trial,” Transplantation; vol. 80 No. 11, pp. 1556-1559 (Dec. 15, 2005).
Liu et al., “Effect of three different curcumin pigmens on the prdiferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R,” Zhongguo Zhong Yao Za Zhi; vol. 31 No. 6, pp. 500-503 (Mar. 2006). [abstract only included herewith].
Tohda et al., “Comparison of Anti-Inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated byCurcuma phaeocaulisExtract,” Evidence-based Complementary and Alternative Medicine; vol. 3 No. 2, pp. 255-260 (2006).
Sharma et al., “Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats,” Clinical and Experimental Pharmacology and Physiology; vol. 33 No. 10, pp. 940 (Oct. 2006).
Kuwabara et al., “Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy,” Urology; vol. 67 No. 2, pp. 440-446 (Feb. 2006).
Ali et al., “Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats,” Fundamental and Clinical Pharmacology; vol. 19 No. 4, p. 473 (Aug. 2005).
Balogun et al., “Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells,
Berkson Lindsey
Burton Kenneth G.
Leith Patricia
Patton & Boggs LLP
LandOfFree
Composition for treating a dermal anomaly does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition for treating a dermal anomaly, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition for treating a dermal anomaly will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4175414