Therapeutic proline derivatives

Details Therapeutic proline derivatives Therapeutic proline derivatives

2003-10-30

2010-02-09

Marschel, Ardin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

07659305

ABSTRACT:
The compounds of formula (I) or a pharmaceutically acceptable salt, solvate or pro-drug thereof, are proline derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, fibromyalgia, arthritis, neuropathalogical disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.

REFERENCES:
patent: 4024175 (1977-05-01), Satzinger et al.
patent: 4087544 (1978-05-01), Satzinger et al.
patent: 4311705 (1982-01-01), Ondetti et al.
patent: 4316905 (1982-02-01), Krapcho
patent: 4316906 (1982-02-01), Ondetti et al.
patent: 4462943 (1984-07-01), Petrillo, Jr. et al.
patent: 5385889 (1995-01-01), Kyle et al.
patent: 0499873 (1992-02-01), None
patent: 0979817 (1998-03-01), None
patent: 1129706 (2001-09-01), None
patent: 0574174 (2003-08-01), None
patent: 2028327 (1980-03-01), None
patent: 2078733 (1982-01-01), None
patent: 2205832 (1998-12-01), None
patent: 04154731 (1992-05-01), None
patent: WO 95/13069 (1995-05-01), None
patent: WO9513069 (1995-05-01), None
patent: WO9961424 (1999-04-01), None
patent: WO01/19817 (2001-03-01), None
patent: WO0162728 (2001-08-01), None
patent: WO 0162757 (2001-08-01), None
patent: WO02/22568 (2002-03-01), None
patent: WO02/30871 (2002-04-01), None
patent: WO02/22575 (2003-03-01), None
IUPAC Compendium of Chemical Terminology. “Cis-Trans Isomers”. [Online] 1997 [Retrieved on Sep. 6, 2007]. Retrieved from the Internet: <URL: http://www.iupac.org/goldbook/C01093.pdf>.
Julien RM. “Chapter 2: Pharmacodynamics: How Drugs Act”. A Primer of Drug Action (Ninth Edition). Worth Publishers, 2001:37-57.
Misra R, “Interphenylene 7-Oxabicyclo[2.2.1]heptane Oxazoles. Highly Potent, Selective and Long-Acting Thromboxane A2 Receptor Antagonists” J. Med. Chem 1998, pp. 1401-1417, vol. 36.
Papaioannou D, “Simple Synthesis of cis-4-Hydroxy-L-Proline and Derivatives Suitable for Use as Intermediates in Peptide Synthesis” Acta Chem Scand 1990, pp. 243-251 vol. 44.
Murakami, Y, Stereochemical Studies. XIII.1) Determination of the Absolute configuration of Mecraptosuccinic Acid by Chemical Correlation with Glyceraldehyde2) Chem. Pharm. Bull, 1972 pp. 543-549 vol. 20.
Eswarakrishnan, V. “Sulfinic Acids and Related Compounds. 13. Unsymmetrical Disulfides Based on Methyl 4-Mercaptobutanesulfinate adn 4(S)- or 4(R)-Mecraptorprolines” J. Org. Chem 1981 pp. 4182-4187 vol. 46.
Ezquerra J, “Synthesis of Enantiomerically Pure 4-Substituted Glutamic Acids and Prolines; General Aldol Reaction of Pyroglutamate Lactam Lithium Enolate Mediated by Et20-BF3” J. Org. Chem., 1995, pp. 2925-2930, vol. 60.
Gee, N “The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the alpha2beta Subunit of a Calcium Channel” J. Biol Chem. 1996, pp. 5768-5776, vol. 271(10).
Gong H, “Tissue-specific Expression and Gabapentin-Binding Properties of Calcium Channel alpha 2 beta Subunit Subtypes” J Membrane Biol, 2001 pp. 35-43 vol. 184.
Krapch J, “ANgiotensin-Converting Enzyme Inhibitors, Mercaptan, Carboxyalky Dipeptide, and Phosphinic Acid Inhibitors Incorporating 4-Substituted Prolines” J. Med. Chem, 1998 pp. 1148-1160 vol. 31.
Marais E, “Calcium Channel alpha2beta Subunites-Structure and Gabapentin Binding” Molecular Pharm, 2001 pp. 1243-1248, vol. 59.
Plucinska K, “Multiple Binding Modes for the Receptor-Bound Conformations of Cyclic AII Agonists” J. Med. Chem., 1993, pp. 1902-1913, vol. 36.
Qin N, “Molecular Cloning and Characterization of the Human Voltage-Gated Calsium Channel alpha 2 beta-4 Subunit” Molecular Pharm 2002 pp. 485-496, vol. 62.
Verbiscar A, “Synthesis of cis-and trans- 4-Mercapto-L-proline Derivatives” J. Org. Chem., 1970 pp. 1924-1927, vol. 35 No. 6.
Ezquerra, J., et al.,J. Org. Chem., vol. 60, pp. 2925-2930 (1995).

Affiliated with

Also associated with

Rating

Therapeutic proline derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic proline derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic proline derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4174631