Fluorescence tomography using line-by-line forward model

Details Fluorescence tomography using line-by-line forward model Fluorescence tomography using line-by-line forward model

2007-06-15

2010-10-12

Geisel, Kara E (Department: 2877)

Optics: measuring and testing

By dispersed light spectroscopy

With sample excitation

C600S317000

Reexamination Certificate

active

07812945

ABSTRACT:
A fluorescence optical tomography system and method uses a photon migration model calculator for which absorption and reduced scattering coefficient values are determined for each source/detector pair. The coefficient values may be determined by measurement, in which a time resolved detector detects the excitation wavelength and generates temporal point spread functions from which the coefficient values are found. Alternatively, the coefficient values may be determined by calculating them from a dataset containing a spatial distribution of absorption and reduced scattering coefficients in a volume of interest. The fluorescence detection may be continuous wave, time resolved, or a combination of the two. An estimator uses a detected fluorescence signal and an estimated fluorescence signal to estimate the image values.

REFERENCES:
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patent: 6825928 (2004-11-01), Liu et al.
patent: 2004/0015062 (2004-01-01), Ntziachristos et al.
patent: 2008/0146897 (2008-06-01), Alfano et al.

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