Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-01-17
2010-11-30
Yang, N C (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S532000, C424S130100, C424S178100
Reexamination Certificate
active
07842465
ABSTRACT:
A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 μm or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.
REFERENCES:
patent: 4556903 (1985-12-01), Blitchington et al.
patent: 2003/0082105 (2003-05-01), Fischman et al.
patent: 2004/0071330 (2004-04-01), Curry
patent: 2004/0071332 (2004-04-01), Bruce et al.
patent: 2004/0091483 (2004-05-01), Weimbs et al.
Krivacic, Robert T., et al., “A rare-cell detector for cancer”, Proceedings of the National Academy of Sciences of the U.S. of America, Jul. 20, 2004, vol. 101, No. 29, pp. 10501-10504.
Curry, D. N., et al., “High-speed detection of occult tumor cells in peripheral blood”, Proceeding sof the 26thAnnual International Conference of the IEEE EMBS, San Francisco, CA, Sep. 1-5, 2004, pp. 1267-1270.
Hsieh, H. Ben, et al., “High speed detection of circulating tumor cells”,Biosensors&Bioelectronics, Elsevier Science Publishers, Barking, GB, vol. 21, No. 10, Apr. 15, 2006, pp. 1893-1899.
European Search Report, Application No. 07100507.8-2204; Dated Jun. 12, 2007, Munich, Germany.
Bruce Richard H.
Curry Douglas N.
Hsieh Huangpin Ben
Krivacic Robert T.
Lazarus Nicole H.
Fay Sharpe LLP
Palo Alto Research Center Incorporated
Yang N C
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