siRNA targeting beta secretase (BACE)

Details siRNA targeting beta secretase (BACE) siRNA targeting beta secretase (BACE)

2009-12-11

2010-10-05

Angell, J. E (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07807820

ABSTRACT:
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for BACE.

REFERENCES:
patent: 7371735 (2008-05-01), Harel-Bellan
patent: 7459547 (2008-12-01), Zamore
patent: 7655788 (2010-02-01), Khvorova
patent: 7655789 (2010-02-01), Khvorova
patent: 7662950 (2010-02-01), Khvorova
patent: 7666853 (2010-02-01), Khvorova
patent: 7674896 (2010-03-01), Khvorova
patent: 7678896 (2010-03-01), Khvorova
patent: 7691997 (2010-04-01), Khvorova
patent: 7691998 (2010-04-01), Khvorova
patent: 7696344 (2010-04-01), Khvorova
patent: 2004/0014956 (2004-01-01), Woolf
patent: 2008/0108583 (2008-05-01), Feinstein
patent: 2008/0287382 (2008-11-01), Feinstein
patent: 2009/0082291 (2009-03-01), Feinstein
patent: 2009/0105173 (2009-04-01), Feinstein
patent: 2010/0029746 (2010-02-01), Feinstein
patent: WO9955910 (1999-11-01), None
patent: WO0044194 (2000-07-01), None
patent: WO0044895 (2000-08-01), None
patent: WO0136646 (2001-05-01), None
patent: WO0168836 (2001-09-01), None
patent: WO02055693 (2002-07-01), None
patent: WO02059300 (2002-08-01), None
patent: WO03064626 (2003-02-01), None
patent: WO03064625 (2003-08-01), None
patent: WO03070918 (2003-08-01), None
patent: WO03074654 (2003-09-01), None
patent: WO03062394 (2003-10-01), None
patent: WO2004111191 (2004-02-01), None
patent: WO2005062937 (2005-07-01), None
patent: WO2007087451 (2007-08-01), None
patent: WO2009001359 (2008-12-01), None
patent: WO2009044392 (2009-04-01), None
Chalk, et al. (2004) Improved and automated prediction of effective siRNA. Biochem Biophys Res Comm 319:264-274.
Fire et al., (1998) Potent and specific genetic interference by double stranded RNA inCaenorhabditis elegans, Nature 391: 806-811.
McManus and Sharp (2002) Gene silencing in mammals by small interfering siRNAs. Nature Reviews Genetics 3:737-747.
Scherer and Rossi. (2003) Approaches for the sequence specific knockdown of mRNA. Nat. Biotechnol. 21 (12):1457-1465.
Scherer and Rossi. (2004) Therapeutic Applications of RNA Inferferences: Recent Advances in siRNA Design. Advances in Genetics 22:1-21.

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