Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-11-05
2010-10-26
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100
Reexamination Certificate
active
07820382
ABSTRACT:
A method for the early diagnosis of breast, lung, pancreatic and colon growths and cancers as well as conditions associated with donor and recipient organ transplants, both before and after transplantation to identify and allow treatment of possible transplanted organ rejection and other disease conditions related and unrelated to the transplantation, compares the gene expression patterns from a patient's peripheral blood monocytes-lymphocyte's gene system with either the similar gene expression patterns of a normal person, or with the similar gene expression patterns of a person known to have the condition being screened for. Differences between the patient's gene expression patterns for particular genes and the normal patterns indicates the presence of the condition with the number of differences indicating the probability of the condition. Similarities between the patient's gene expression patterns for those particular genes and the patterns of a person known to have the condition indicates the presence of the condition with the number of similarities indicating the probability of the condition. For example, particular genes for use in identifying pancreatic cancer are disclosed.
REFERENCES:
patent: 6905827 (2005-06-01), Wohlgemuth et al.
patent: 2001/0051344 (2001-12-01), Shalon et al.
patent: 2004/0009147 (2004-01-01), Ebner et al.
patent: 2004/0110221 (2004-06-01), Twine et al.
patent: 2004/0146921 (2004-07-01), Eveleigh et al.
patent: 2004/0229349 (2004-11-01), Daridon
patent: 2005/0152908 (2005-07-01), Liew et al.
patent: 2007/0037144 (2007-02-01), Wohlgemuth et al.
patent: WO 0020013 (2000-04-01), None
patent: WO 02/059367 (2002-08-01), None
patent: WO-03-090694 (2003-11-01), None
patent: WO2004/048933 (2004-06-01), None
Paweletz et al, in Microarrays and Cancer Research, 2002, Warrington et al (eds.), Eaton Publishing, Westborough, MA, pp. 61-77.
Staynov et al, Immunology 75: 196 (1992).
Villa-Komaroff et al, Methods Enzymol. 30: 709 (1974).
Axis-Shield LymphoprepTM Product Description (Mar. 2003).
Xu T, Shu CT, Purdom E, Dang D, Iisley D, Guo Y, Weber J, Holmes SP, Lee PP, Microarray analysis reveals differences in gene expressions of circulating CD8(+) T cells in melanoma patients and healthy donors, Cancer Research, May 15, 2004, 21(1), p. 21-4.
Hong, MH, Xiao XB, Mai HQ, Cao SM, Min HQ, Analysis of gene expression patterns of periphery lymphocytes in patients with nasopharyngeal carcinoma, Ai Zheng, Jan. 2002, 21(1), o. 21-4, www.ncbi.nlm.nih.gov/entrez/query.
Twine NC, Stover JA, Marshall B, Dukart G, Hidalgo M, Stadler W, Logan T, Dutcher J, Hudes G, Dorner AJ, Slonim DK, Trepicchio WL, Burczynski ME, Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma, Sep. 15, 2003, 6069-75, 63(18).
Thomas AM et al., Mesothelin-specific CD 8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic patients. J Exp Med., Aug. 2004, 200(3): 297-306.
McLaren PJ et al., Antigen-specific gene expression profiles of peripheral blood mononuclear cells do not reflect those T-lymphocyte subsets, Clin Diagn Lab Immunol, Sep. 2004, 11(5), 977-82.
Burczynski ME, Transcription profiles in peripheral blood mononuclear cells prognositic clinical outcomes in patients with advanced renal cell carcinoma, Clinical Cancer Research., Feb. 2005, 11(3), 1181-9.
Lucentini, J., Gene Association Studies Typically Wrong, The Scientist, 2004, 18(24):20.
Kroese et al. Genetic Tests and Their Evaluation: Can We Answer the Key Questions? Genetics in Medicie, 2004, 6(6): 475-480.
Deprimo, et al., Expression profiling of blood samples from an SU5416 Phase III metastatic colorectal cancer clinical trial: a novel strategy for biomarker identification, Feb. 7, 2003, 12 pages, 3:3, http://www.biomedcentral.com/1471-2407/3/3.
Lockhart et al., Expression Monitoring by Hybridization to High-Density Oligonucleotide Arrays, Nature Biotechnology, 1996, 1675-1680, (14)13.
Ringel et al., (Proceeding of the American Association of Cancer Research (2001) vol. 42 p. 616, abstract 3311).
Benner et al., (Trends in Genetics (2001) vol. 17, pp. 414-418).
Vandesompele et al., (Genome Biology(2002) vol. 3, pp. 1-11.
Cheung et al., (Nature Genetics, 2003, vol. 33, pp. 422-425).
Wu (Journal of Pathology, 2001, vol. 195, pp. 53-65).
Newton et al., (Journal of Computational Biology, 2001, vol. 8, pp. 37-52).
NCBI website. Nucleotide search-alcam-Nucleotide Results. (http:/
cbi.nlm.nih.gov/sites/entrez) (pp. 1-2, Oct. 29, 2008).
Oncogenomics website. Pediatric Xenograft & Tumor Gene Expression Database—Details page (http://pob.abcc.ncifcrf.gov/cgi-bin/JK) Oct. 28, 2008, pp. 1-3.
Mannick et al., Gene expression in mononuclear cells from patients with inflammatory bowel disease. Clinical Immunology 112 (2004) 247-257.
GenBank accession NM—145345.1 GI:21703361 (Sep. 3, 2004).
Oncogenomics (download Sep. 30, 2009).
GenBank Accession NM—183008.2 Gl:41281992 (Jan. 2004).
Entrez Gene 91544 (downloaded Sep. 30, 2009).
LaTulippe et al (Cancer Research (2002) vol. 62, pp. 4499).
Affymetrix (website Downloaded Mar. 13, 2010). Probe Sets HG-U95D:86652—AT, HG-U95AV2:41409—AT, HG-95E:67449—F—AT, and HG-U95B:58233—AT.
Greenbaum et at (Genome Biology 2003, vol. 4, article 117, pp. 1-8).
Martinell James
Thorpe North & Western LLP
LandOfFree
Method for the early detection of breast cancer, lung... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the early detection of breast cancer, lung..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the early detection of breast cancer, lung... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4172159