Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-11-13
2010-12-28
Shameem, Golam M (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S311100, C548S311400, C548S312100, C546S112000, C546S152000, C514S299000, C514S311000, C514S385000
Reexamination Certificate
active
07858652
ABSTRACT:
The present invention relates to a compound of formula I,whereinR1is selected from the group consisting of hydrogen and lower alkyl;each R2is independently selected from the group consisting of hydrogen and lower alkyl;each R3is independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, phenyloxy, benzyloxy, halogen and lower alkyl substituted by halogen;R4is selected from the group consisting of hydrogen and lower alkyl;X is selected from the group consisting of —CH2—, —CH— and —O—;Y is selected from the group consisting of —CH2—, —CH2CH2—, —CH— and a bond; with the proviso that, when X is —O—, Y is —CH2—;Z is selected from the group consisting of —CH2— and —CH—;m is 1 or 2; andn is 1 or 2.The invention relates also to a pharmaceutically-acceptable acid-addition salt of such a compound, methods for making the compound, and a composition comprising such a compound.It has been found that the compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1.
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Galley Guido
Groebke Zbinden Katrin
Norcross Roger
Stalder Henri
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
Shameem Golam M
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