Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-09-09
2010-02-09
Kam, Chih-Min (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S383000, C530S350000
Reexamination Certificate
active
07659247
ABSTRACT:
This invention relates to a process for the production of a von Willebrand factor preparation having a high specific activity, hydroxylapatite being used as a chromatography medium.
REFERENCES:
patent: 5128245 (1992-07-01), Greenberg et al.
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Gorman, J. J. et al., “Studies on The Structure and Subunit Composition of Human Antihaemophilic Factor”, Thrombosis Research, vol. 12, pp. 341-352 (1978).
Saundry, R. H. et al., “Chromatography of vWF on Dextran Sulphate Sepharose”, Thrombosis Research, vol. 48, pp. 641-652 (1987).
Janson, J.C. et al. (editors), “Protein Purification: Principles, High Resolution Methods, and Applications”, Second edition, Wiley-Liss, NY, pp. 190-191, 199-200 (1998).
Bernardi, Giorgio, “Chromatography of Proteins on Hydroxyapatite”, Methods in Enzymology, vol. 27, pp. 471-479 (1973).
Barington, K. A. et al., “A Very High Purity Von Willebrand Factor Preparation Containing High Molecular Weight Multimers”, Vox Sanguinis, vol. 76, pp. 85-89 (Mar. 1999).
Lethagen, S. et al., “A Comparative In Vitro Evaluation of Six Von Willebrand Factor Concentrates”, Haemophilia, vol. 10, No. 3, pp. 243-249 (May 2004).
Burnouf-Radosevich, M. et al., “Chromatographic Preparation of a Therapeutic Highly Purified Von Willebrand Factor Concentrate from Human Cryoprecipitate”, Vox Sanguinis, vol. 62, No. 1, pp. 1-11 (1992).
Veyradier, A. et al., “Laboratory Diagnosis of Von Willebrand Disease”, vol. 28, No. 4, pp. 201-210 (Dec. 1998).
Written Opinion of the International Searching Authority issued in PCT/EP05/009729 (PCT/ISA/237), (Jan. 2004).
Kretschmar Michael
Moeller Wolfgang
Biotest AG
Kam Chih-Min
Smith Chalin
Smith Patent Consulting LLC
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