Heterocyclic derivatives

Details Heterocyclic derivatives Heterocyclic derivatives

2007-06-29

2010-10-26

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S406000, C548S361100, C548S365700

Reexamination Certificate

active

07820707

ABSTRACT:
The present invention relates to a heterocyclic derivative according to formula Iwherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising said heterocyclic derivatives and to their use in therapy, for instance in the treatment or prevention of psychiatric diseases where an enhancement of synaptic responses mediated by AMPA receptors is required, including schizophrenia, depression and Alzheimer's disease.

REFERENCES:
patent: 2004/0171603 (2004-09-01), Pato
patent: WO 2005/033102 (2005-04-01), None
patent: WO 2005/040110 (2005-05-01), None
patent: WO 2005/070916 (2005-08-01), None
patent: WO 2006/044826 (2006-04-01), None
“Depression.” Retrieved online via the internet [Mar. 24, 2009] URL: http://www.nlm.nih.gov/medlineplus/depression.html.
“Alzheimer's Stages.” Retrieved online via the internet [Mar. 24, 2009] URL: http://www.mayoclinic.com/health/alzheimers-stages/AZ00041.
“Alzheimer's Treatment.” Retrieved online via the internet [Mar. 24, 2009] URL: http://www.medindia.net/patients/patientinfo/Alzheimers—treatment.htm.
Morissette et al. Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.
Arai et. al., “Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action,”J Pharmacol Exp. Ther. 303(2002) 1075-1085.
Pirotte et al., “4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure-Activity Relationships,”J Med Chem. 41(1998) 2946-2959.
Lynch, G., “Glutamate-based therapeutic approaches: ampakines,”Current Opinion in Pharmacology 6(2006) 82-88.
Ornstein et. al., “Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)-propanoic Acid (AMPA) Receptors,”J Med. Chem. 43(2000) 4354-4358.
Yamada, K.A., “Therapeutic Potential of Positive AMPA Receptor Modulators in the Treatment of Neurological Disease,”Exp. Opin. Invest. Drugs 9(2000) 765-778.
Abstract; Acc. No. 2004:1697041; Chembridge Screening Library; Jan. 12, 2005; Reg. No. 332944-69-1.
Abstract; Acc. No. 2004:1695877; Chembridge Screening Library; Jan. 12, 2005; Reg. No. 332944-89-5.
Abstract; Acc. No. 2004:1700663; Chembridge Screening Library; Jan. 12, 2005; Reg. No. 332944-91-9.
Abstract; Acc. No. 2004:3287067; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 489408-02-8.
Abstract; Acc. No. 2004:2935795; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 489407-99-0.
Abstract; Acc. No. 2004:2944145; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 332943-84-7.
Abstract; Acc. No. 2004:2935795; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 489407-99-0.
Abstract; Acc. No. 2004:3286992; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 512809-08-4.
Abstract; Acc. No. 2004:2948236; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 332944-93-1.
Abstract; Acc. No. 2004:3293567; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 512808-90-1.
Abstract; Acc. No. 2004:2894847; TimTec Overseas Stock; Aug. 1, 2005; Reg. No. 491831-90-4.
Abstract; Acc. No. 2001:2277483; ChemDiv. Inc. Proudct Library; Apr. 25, 2003; Reg. No. 357611-67-7.
Abstract; Acc. No. 2001:907829; AsInEx Express Gold Collection; Jan. 31, 2006; Reg. No. 332943-95-0.
Abstract; Acc. No. 2001:711318; AsInEx Express Gold Collection; Jan. 31, 2006; Reg. No. 332943-93-8.
Abstract; Acc. No. 2000:914363; ChemStar Product List; Apr. 6, 2006; Reg. No. 299406-09-0.
International Search Report for PCT/EP2007/005851 mailed Nov. 6, 2007.
Written Opinion for International Application No. PCT/EP2007/005851 mailed on Nov. 6, 2007.

Affiliated with

Also associated with

Rating

Heterocyclic derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4167897