Selectively permeable membranes on porous substrates

Details Selectively permeable membranes on porous substrates Selectively permeable membranes on porous substrates

2006-06-16

2010-11-16

Conley, Sean E (Department: 1797)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

C435S287300, C435S289100, C428S304400, C422S105000

Reexamination Certificate

active

07833805

ABSTRACT:
Functional biological synthetic composite (BSC) membranes comprising phospholipids, biological membrane proteins and porous supports or membranes are provided. Lipid bilayers are formed on porous polycarbonate (PC), polyethylene terephthalate (PETE) and poly (I-lactic acid) (PLLA) membranes and in laser-drilled pores in a multi-well plastic plate as measured by increased resistance or decreased currents. BSC's comprising functional reconstituted Kv1.5 K channel and/or H/K ATPase transport proteins are also provided c inhibitor), methods of manufacture, and high throughput screening assays employing the inventive membranes are also provided.

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