Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-08-04
2010-06-01
Weddington, Kevin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S458000
Reexamination Certificate
active
07728038
ABSTRACT:
The invention relates to compositions and methods of treatment using an iron chelator, an antioxidant, estrogen, and/or combinations thereof, optionally, linked to a nanoparticle, to treat a subject in need thereof. The compositions and methods may be used to restore or protect the normal functions of osteoblast and osteoclast by depleting iron and inhibiting oxidative damage. The compositions and methods may also be used to increase the bone formation rate in a subject.
REFERENCES:
patent: 6677320 (2004-01-01), Diederich et al.
patent: 6767702 (2004-07-01), Mirkin et al.
Ima-Nirwana et al., “Palm Vitamin E Improves Bone Metabolism and Survival Rate in Throtoxic Rats”, General Pharmacology, Vo. 32, No. 5, pp. 621-626 (May 1999), see enclosed abstract.
Miller et al., “Duration and Dose-Related Effects of an Orally Administered, Partially Lipophilic Polyaminocarboxylic Acid on the Decorporation of Plutonium and Americium”, The Journal of Pharmacology and Experimental Therapeutics, vol. 267, No. 1, pp. 548-554 (1993).
Chaves et al., “Alkylaryl-amino derivatives of 3-hydroxy-4-pyridinones as aluminium chelating agents with potential clinical application”, Journal of Inorganic Biochemistry, vol. 97, No. 1, pp. 161-172 (2003).
Liu Gang
Men Ping
Ballard Spahr LLP
University of Utah Research Foundation
Weddington Kevin
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