Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-12-10
2010-11-23
Low, Christopher (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
Reexamination Certificate
active
07838504
ABSTRACT:
Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of viral genome in the target cell, e.g., by introducing a miRNA inhibitory agent in the target cell. Also provided are pharmaceutical compositions, kits and systems for use in practicing the subject methods. The subject invention finds use in a variety of applications, including the treatment of subjects suffering from a viral mediated disease condition, e.g., an HCV mediated disease condition.
REFERENCES:
patent: 7232806 (2007-06-01), Tuschi et al.
patent: 2002/0119122 (2002-08-01), Stalgis et al.
patent: 2004/0175732 (2004-09-01), Rana
patent: 2004/0229817 (2004-11-01), Duggal et al.
patent: 2005/0227256 (2005-10-01), Hutvagner et al.
patent: WO02/081494 (2002-10-01), None
patent: WO03/029459 (2003-04-01), None
patent: 2004076622 (2004-09-01), None
Baskerville and Bartel, “Microarray Profiling of MicroRNAs Reveals Frequent Coexpression with Neighboring miRNAs and Host Genes,” (2005) RNA, 11:241-247.
Bennasser et al., “HIV-I Encoded Candidate Micro-RNAs and Their Cellular Targets,” (2004) Retrovirology, 1:43.
Boutla et al., “Developmental Defects by Antisense-Mediated Inactivation of Micro-RNAs 2 and 13 inDrosphillaand the Identification of Putative Target Genes,” Nucleic Acids Research (2003) 31(17):4973-4980.
Chen, “A microRNA as a Translational Repressor of APETALA2 in Arabidopsis Flower Development,” (2004) Science, 303:2022-2025.
Crooke (2001) in Antisense Drug Technology, Chapter 1, Basic Principles of Antisense Technology, pp. 1-28 (Springer-Vertag).
Cullen, “Derivation and Funciton of Small Interering RNAs and MicroRNAs,” Virus Research (2004) 102:3-9.
Doench and Sharp, “Specificity of MicroRNA Target Selection in Translational Repression,” (2004) Games 7 Development, 504-511.
Doench et al., “sIRNAs Can Function as miRNAs,” (2003) Genes & Development, 17:438-442.
Friebe et al., “Sequences in the 5' Nontranslated Region of Hepatitis C Virus Required for RNA Replication,” (2001) Journal of Virology, 75(24):12047-12057.
Hutvagner and Zamore, “A MicroRNA in a Multiple-Turnover RNAi Enzyme Complex,” (2002) Science, 297:2056-2060.
Hutvagner et al. (2004) PIoS Biology 2:0465-0475.
Ikeda et al., “Selectable Subgenomic and Genome Length Dielstronic RNAs Derived from an Infectious Molecular Clone of the HCV-N. Strain of Hepatitis C Virus Replicate Efficiently in Cultured Huh7 Cells,” (2002) Journal of Virology, 76(6):2997-3006.
Jen et al., (2000) Stem Cells 18:307-319.
John et al., “Human MicroRNA Targets,” (2004) PLoS Biology, 2(11):1862-1879.
Kassachau et al., “P1/HC-Pro, A Viral Suppressor of RNA Silencing, Interferes with Arabidopsis Development and MiRNA Function,” Development Cell (2003) 4:205-217.
Lagos-Quintana, et al., “Identification of Tissue-Specific MicroRNAs from Mouse,” (2002) Current Biology, 12:736-739, including Supplementary Material, pp. S1-S15.
Lewis et al., “Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets,” (2005) Cell, 120:15-20.
Lewis, et al., “Prediction of Mammalian MicroRNA Targets,” (2003) Cell,' 115:787-798.
Lim, et al., “Microarray Analysis Shows that Some MicroRNAs Downregulate Large Numbers of Target mRNAs,” (2005) Nature, 433:769-773.
Lu et al, (2005) in RNA Interference Technology (Cambridge, Appasani, ed.).
Meister et al. “Sequence-specific inhibition of microRNA-and SiRNA-induced RNA silencing”, (2004) RNA 10:544-550.
Olsen and Ambros, “The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis Elegans by Blocking LIN-14 Protein Synthesis After the Initiation of Translation,” (1999) Developmental Biology, 216:671-680.
Pfeffer et al., “Identification of Virus-Encoded MicroRNAs,” (2004) Science, 304:734-736.
Saxena et al., “Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation,” (2003) the Journal of Biological Chemistry, 276(45):44312-44319.
Sempere et al., “Expression Profilling of Mammalian MicroRNAs Uncovers a Subset of Brain-Expressed MicroRNAs with Possible Roles in Murine and Human Neuronal Differentiation,” (2004) Genome Biology 5:3:R13.
Sunkar and Zhu, “Novel and Stress-Regulated MicroRNAs and Other Small RNAs from Arabidopsis,” (2004) The Plant Cell, 16:2001-2019.
Taylor et al., “Hepatitis Delta Virus Replication and Liver Disease,” (2004) RNA Biology 1:106.
Tomari and Zamore, “Perspective: machines for RNA1,” (2005) Genes & Development 19:517-529.
Yetka et al., “MicroRNA-Directed Cleavage of HOXB8 mRNA,” (2004) Science, 304:594-596.
Zeng et al., “MicroRNAs and Small Interfering RNAs Can Inhibiti mRNA Expression by Similar Mechanisms,” (2003) Proc. Natl. Acad. Sci. USA, 100(17):9779-9787.
International Search Report, PCT/US2005/015264, dated Nov. 21, 2005, 5 pages.
McCaffrey et al. “RNA interference V in adult mice” Nature, vol. 418, No. 6893, Jul. 4, 2002, pp. 38-39.
Meister, et al. “Sequence-specific 1-19 C12N inhibition of microRNA- and siRNA-induced A61K RNA silencing” RNA, vol. 10, No. 3, Mar. 1, 2004, pp. 554-550.
Jopling, et al. “Modulati on of hepatitis C virus RNA abundance by a liver-specific microRNA” Science, vol. 309, No. 5740, Sep. 1, 2005, pp. 1577-1581.
Jopling Catherine L.
Lancaster Alissa M.
Sarnow Peter
Jones S.C. Casimir
Low Christopher
The Board of Trustees of the Leland Standford Junior University
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