Methylation of estrogen receptor alpha and uses thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C536S023100, C536S023500, C536S024100

Reexamination Certificate

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07829283

ABSTRACT:
Methods for diagnosis, prognosis, and treatment of cancer based on the methylation status of the ER-α gene promoter are disclosed. Methylation of the ER-α gene promoter is indicative of cancer and unfavorable prognosis. The cancer can be treated with a demethylation agent.

REFERENCES:
patent: 7635561 (2009-12-01), Giordano
patent: 2007/0092498 (2007-04-01), Giordano
patent: 2005027712 (2005-03-01), None
Mori et al. Cancer Research. Jul. 1, 2006. 66(13): 6692-669.
Martinez et al. Journal of Clinical Oncology. 2006. Supplement 1. 24 (18S) Abstract 8026.
Nimmrich et al. Breast Cancer Research and Treatment. 2008. 111:429-437.
Ehrlich et al. Oncogene 2002. 21: 5400-5413.
Nishiyama et al. Cancer Biology and Therapy. 2005. 4: 440-448.
Battagli et al. Cancer Research. Dec. 2003. 63: 8695-8699.
Mori et al., “Predictive Utility of Circulating Methylated DNA in Serum of Melanoma Patients Receiving Biochemotherapy” Journal of Clinical Oncology, vol. 23, No. 36, pp. 9351-9358, Dec. 20, 2005.
Taback et al., “Quantification of Circulating DNA in the Plasma and Serum of Cancer Patients” Annuala of the New York Academy of Sciences, vol. 1022, pp. 17-24, 2004.
Goyal et al., “Detection of Micrometastases in Paraffin Embedded Lymph Nodes by Methylation-Specific PCT (MSP) in Patients with Breast Carcinoma” Breast Cancer Research and Treatment, vol. 82, No. Suppl. 01, p. S43, Jan. 1, 2003.
Hoon et al., “Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients” Oncogene, Nature Publishing Group, vol. 23, No. 22, pp. 4014-4022, May 13, 2004.
Yang et al., “Synergistic Activation of Functional Estrogen Receptor (ER)-alpha by DNA Methyltransferase and Histone Deacetylase Inhibition in Human ER-alpha-negative Breast Cancer Cells” Cancer Research, vol. 61, pp. 7025-7029, Oct. 1, 2001.
Mori et al., “Estrogen Receptor-alpha Methylation Predicts Melanoma Progression” Cancer Research, vol. 66, No. 13, pp. 6692-6698, Jul. 1, 2006.
European search report for corresponding European application 07754527 lists the references above.

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