Methods and compositions for transcription-based nucleic...

Details Methods and compositions for transcription-based nucleic... Methods and compositions for transcription-based nucleic...

2007-10-31

2010-12-07

Strzelecka, Teresa E (Department: 1637)

Chemistry: molecular biology and microbiology

Kit

C536S023100, C536S024300

Reexamination Certificate

active

07846733

ABSTRACT:
Methods for isothermal exponential amplification of a target polynucleotide are disclosed. The methods employ two transcription modules, the first module providing linear amplification resulting in RNA transcripts, and a second module providing for further (generally cyclical) amplification resulting in more RNA transcripts. In one aspect, the amplification of the first module is composite primer based. In a second aspect, the amplification of the first module is based on target switching to generate a primer extension product comprising a promoter sequence. In all aspects, the RNA transcripts of the first transcription module are subjected to further amplification by creating an intermediate product comprising a double stranded promoter region from which transcription can occur. The invention further provides compositions and kits for practicing said methods, as well as methods which use the amplification results.

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