Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-16
2010-12-07
Nashed, Nashaat T (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S134000, C435S193000, C435S252300, C435S252700, C435S320100, C435S419000
Reexamination Certificate
active
07847077
ABSTRACT:
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
REFERENCES:
patent: 5130242 (1992-07-01), Barclay et al.
patent: 5246841 (1993-09-01), Yazawa et al.
patent: 5310242 (1994-05-01), Golder
patent: 5639790 (1997-06-01), Voelker et al.
patent: 5672491 (1997-09-01), Khosia et al.
patent: 5683898 (1997-11-01), Yazawa et al.
patent: 5798259 (1998-08-01), Yazawa et al.
patent: 5908622 (1999-06-01), Barclay
patent: 6033883 (2000-03-01), Barr et al.
patent: 6140486 (2000-10-01), Facciotti et al.
patent: 6503706 (2003-01-01), Abken et al.
patent: 6566583 (2003-05-01), Facciotti et al.
patent: 7001772 (2006-02-01), Roessler et al.
patent: 7125672 (2006-10-01), Picataggio et al.
patent: 7211418 (2007-05-01), Metz et al
patent: 7214853 (2007-05-01), Facciotti et al.
patent: 7217856 (2007-05-01), Weaver et al.
patent: 7256022 (2007-08-01), Metz et al.
patent: 7256023 (2007-08-01), Metz et al.
patent: 7259295 (2007-08-01), Metz et al.
patent: 7271315 (2007-09-01), Metz et al.
patent: 2002/0138874 (2002-09-01), Mukerji et al.
patent: 2002/0156254 (2002-10-01), Qiu et al.
patent: 2002/0194641 (2002-12-01), Metz et al.
patent: 2004/0005672 (2004-01-01), Santi et al.
patent: 2004/0010817 (2004-01-01), Shockey et al.
patent: 2004/0139498 (2004-07-01), Jaworski et al.
patent: 2004/0172682 (2004-09-01), Kinney et al.
patent: 2005/0014231 (2005-01-01), Mukerji et al.
patent: 2005/0089865 (2005-04-01), Napier et al.
patent: 2005/0164192 (2005-07-01), Graham et al.
patent: 2007/0244192 (2007-10-01), Metz
patent: 2007/0245431 (2007-10-01), Metz et al.
patent: 2007/0256146 (2007-11-01), Metz et al.
patent: 2007/0270494 (2007-11-01), Metz et al.
patent: 2008/0022422 (2008-01-01), Weaver et al.
patent: 2008/0026434 (2008-01-01), Weaver et al.
patent: 2008/0026435 (2008-01-01), Weaver et al.
patent: 2008/0026438 (2008-01-01), Metz et al.
patent: 2008/0026439 (2008-01-01), Metz et al.
patent: 2008/0026440 (2008-01-01), Metz et al.
patent: 2008/0032351 (2008-02-01), Metz et al.
patent: 2008/0038378 (2008-02-01), Metz et al.
patent: 2008/0038379 (2008-02-01), Metz et al.
patent: 2008/0038790 (2008-02-01), Metz et al.
patent: 2008/0038791 (2008-02-01), Metz et al.
patent: 2008/0038792 (2008-02-01), Metz et al.
patent: 2008/0038793 (2008-02-01), Metz et al.
patent: 2008/0038794 (2008-02-01), Metz et al.
patent: 2008/0038795 (2008-02-01), Metz et al.
patent: 2008/0038796 (2008-02-01), Metz et al.
patent: 2008/0038797 (2008-02-01), Metz et al.
patent: 2008/0044867 (2008-02-01), Metz et al.
patent: 2008/0044868 (2008-02-01), Metz et al.
patent: 2008/0044869 (2008-02-01), Metz et al.
patent: 2008/0044870 (2008-02-01), Metz et al.
patent: 2008/0044871 (2008-02-01), Metz et al.
patent: 2008/0044872 (2008-02-01), Metz et al.
patent: 2008/0044873 (2008-02-01), Metz et al.
patent: 2008/0050790 (2008-02-01), Metz et al.
patent: 2008/0148433 (2008-06-01), Metz et al.
patent: 2520795 (2004-10-01), None
patent: 0594868 (1994-05-01), None
patent: 0823475 (1998-02-01), None
patent: 9323545 (1993-11-01), None
patent: 9621735 (1996-07-01), None
patent: 9846764 (1998-10-01), None
patent: 9855625 (1998-12-01), None
patent: 0042195 (2000-07-01), None
patent: WO 02/083870 (2002-10-01), None
patent: WO 2004/087879 (2004-10-01), None
patent: WO 2006/008099 (2006-01-01), None
patent: WO 2006/034228 (2006-03-01), None
U.S. Appl. No. 11/674,574, filed Feb. 13, 2007, Facciotti et al.
U.S. Appl. No. 11/777,277, filed Jul. 12, 2007, Metz et al.
U.S. Appl. No. 11/778,594, filed Jul. 16, 2007, Metz et al.
Allen E.A. et al. 2002 “Structure and regulation of the omega-3 polyunsaturated fatty acid synthase genes from the deep-sea bacterium Photobacterium profundum strain SS9” Microbiology vol. 148 pp. 1903-1913.
Cane et al., “Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations.” Science 1998, vol. 282, pp. 63-68.
Chuck et al., “Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase”, Chem and Bio, Current Bio, (London), GB vol. 4, No. 10, 1997, pp. 757-766, XP000884721.
Database Geneseq 'Online! Dec. 11, 2000, “S. aggregatumPKS cluster ORF6 homolog DNA.” XP002368912, retrieved from EBI accession No. GSN:AAA71567Database accession No. AAA71567—& Database Geneseq 'Online! Dec. 11, 2000, “S. aggregatumPKS cluster ORF6 homolog protein.” XP002368914 retrieved from EBI accession No. GSP:AAB10482 Database accession No. AAB10482 & WO 00/42195 A (Calgene, LLC) Jul. 20, 2000.
GenBank Accession No. AF4091 00, (Allen et al.) 2002.
GenBank Accession No. U09865. Alcaligenes eutrophus pyruvate dehydrogenase (pdhA), dihydrolipoamide acetyltransferase (pdhB), dihydrolipoamide dehydrogenase (pdhL), and ORF3 genes, complete cds (1994).
Harlow et al. Antibodies: A Laboratory Manual (1988) Cold Spring Harbor Laboratory Press, p. 76.
Jez et al., “Structural control of polyketide formation in plant-specific polyketide synthases”, Chem and Bio (London), vol. 7, No. 12, Dec. 2000, pp. 919-930, XP002338564.
Kaulmann et al. “Biosynthesis of Polyunsaturated Fatty Acids by Polyketide Synthases”, Angew. Chem. Int. Ed. 2002, 41, No. 11, pp. 1866-1869.
Kealey et al., “Production of a polyketide natural product in non-polyketide-producing prokaryotic and eukaryotic hosts”, Proceedings of the National Academy of Sciences of the United States of America, vol. 95, No. 2, Jan. 20, 1998, pp. 505-509, XP002338563.
Khosla et al., “Tolerance and Specificity of Polyketide Synthases”, Annu. Rev. Biochem. 1999. 68:219-253.
Leadlay PF. “Combinatorial Approaches to Polyketides Biosynthesis” Current Opinion in Chemical Biology (1997) 1: 162-168.
Nasu et al., “Efficient Transformation ofMarchantia polymorphaThat is Haploid and Has Very Small Genome DNA,” Journal of Fermentation and Bioengineering vol. 84, No. 6, 519-523 1997.
Nicholson et al., “Design and utility of oligonucleotide gene probes for fungal polyketide synthases”, Chem & Bio (London) vol. 8, No. 2, Feb. 2001, pp. 157-178, XP002338562.
Oliynuk et al. “A hybrid modular polyketide synthase obtained by domain swapping.” Chemistry & Biology (1996) 3: 833-839.
Orikasa et al. Characterization of the eicosapentaenoic acid biosynthesis gene cluster fromShewanellasp. strain SCRC-2738, Cellular and Molecular Biology (Noisy-le-grand), Jul. 2004, vol. 50, No. 5, pp. 625-630.
Satomi et al.Shewanelia marinintesinasp. nov.,Shewanella schlegelianasp. nov. andShewanelia sairaesp. nov., novel eicosapentaenoic-acid-producing marine bacteria isolated from see-animal intestines. Internat. J. Syst. Evol. Microbiol. 2003, vol. 53, pp. 491-499.
Takeyama et al. Expression of eicosapentaenoic acid synthesis gene clustter fromShewanellasp. in transgenic marine cyanobacterium.Synechecoccussp. Microbiology. 1997, vol. 143, pp. 2725-2731.
UniProt Accession No. Q93CG6—PHOPR, (Allen et al.) 2002.
Wallis et al., “Polyunsaturated fatty acid synthesis: what will they think of next?”, Tibs Trends in Bio Sciences, Elsevier Publ., Cambridge, EN, vol. 27, No. 9, Sep. 2002, pp. 467-473, XP004378766.
Wiesmann et al. “The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.” Biochemistry (1997) 36: 13849-13855.
Wiesmann et al. “Origin of starter units for erythromycin biosynthesis.” Biochemistry (1998) 37: 11012-11017.
Wiesmann et al. “
Barclay William R.
Flatt James H.
Metz James G.
Weaver Craig A.
Martek Biosciences Corporation
Moore William W
Nashed Nashaat T
Sterne Kessler Goldstein & Fox P.L.L.C.
LandOfFree
PUFA polyketide synthase systems and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with PUFA polyketide synthase systems and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PUFA polyketide synthase systems and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4162886