Modulation of telomere length in telomerase positive cells...

Details Modulation of telomere length in telomerase positive cells... Modulation of telomere length in telomerase positive cells...

2006-03-27

2010-06-22

Lewis, Patrick T (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S045000, C514S046000, C514S049000, C514S050000

Reexamination Certificate

active

07741296

ABSTRACT:
Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed.

REFERENCES:
patent: 5166140 (1992-11-01), Scanlon et al.

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