Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Reexamination Certificate
2007-01-09
2010-10-05
Carr, Deborah D (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
Reexamination Certificate
active
07807847
ABSTRACT:
Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
REFERENCES:
patent: 4329302 (1982-05-01), Hanahan et al.
patent: 4614796 (1986-09-01), Kawamata et al.
patent: 4778912 (1988-10-01), Inoue et al.
patent: 4827011 (1989-05-01), Wissner et al.
patent: 5561052 (1996-10-01), Koike
patent: 5660855 (1997-08-01), Malé-Brune
patent: 5985292 (1999-11-01), Fourneron et al.
patent: 6017513 (2000-01-01), Betbeder et al.
patent: 6261597 (2001-07-01), Kurtz
patent: 6838452 (2005-01-01), Harats et al.
patent: 642665 (1984-04-01), None
patent: WO 95/23592 (1995-09-01), None
patent: WO 02/41827 (2002-05-01), None
patent: WO 2004/106486 (2004-12-01), None
International Preliminary Report on Patentability Dated Sep. 15, 2008 From the International Preliminary Examining Authority Re.: Application No. PCT/IL05/00735.
International Search Report and the Written Opinion Dated Aug. 24, 2006 From the International Searching Authority Re.: Application No. PCT/IL05/00735.
Response Dated May 17, 2010 to Examination Report of Dec. 10, 2009 From the Intellectual Property Office of New Zealand Re.: Application No. 553147.
International Preliminary Report on Patentability Dated Oct. 29, 2009 From the International Bureau of WIPO Re.: Application No. PCT/IL2008/000013.
Office Action Dated Nov. 13, 2009 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 200580029218.9 and Translation of Proposed Claims Into English.
Office Action dated Dec. 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/650,973.
Official Action Dated Oct. 29, 2009 From the ROSPATENT, Federal State Office , Federal Institution of Industrial Property of the Federal Office of Intellectual Property, Patents and Trademarks of the Russian Federation Re.: Application No. 2007105097 and Its Translation Into English.
Supplementary Partial European Search Report and the European Search Opinion Dated Nov. 30, 2009 From the European Patent Office Re.: Application No. 05758938.4.
Boullier et al. “The Binding of Oxidized Low Density Lipoprotein to Mouse CD36 Is Mediated in Part by Oxidized Phospholipids That Are Associated With Both the Lipid and Protein Moieties of the Lipoprotein”,Jornal of Biological Chemistry, vol. 275 (13) p. 9163-9169, 2000.
Davies et al. “Oxidized Alkyl Phospholipids Are Specific, High Affinity Peroxisome Proliferator- Activated Receptor γ ligands and Agonists”, Jornal of Biological Chemistry, vol. 26 (19), p. 16015-16023, 2001.
George et al. “Hyperimmunization of Apo-E-Deficient Mice Homologous Malondialdehyde Low-Density Lipoprotein Suppresses early Atherogenesis”, Atherosclerosis 138, p. 147-152, 1998.
Itabe et al. “Oxidized Phosphatidylcholines That Modify Proteins”, Jornal of Biological Chemistry, vol. 271 (52), p. 33208-33217, 1996.
Leitinger et al. “Structurally Similar Oxidized Phospholipids Differentially Regulate Endothelial Binding of Monocytes and Neutrophils”, Proc. Natl. Acad. Sci. USA, 96(21): 12010-12015, 1999.
Subbanagounder et al. “Determinants of Bioactivity of Oxydized Phospholipids: Specific Oxidized Fatty Acyl Groups at the SN-2 Position,” Arteriosclerosis Thromb. Vasc. Biol., p. 2248-2254, 2000.
Subbanagounder et al. “Evidence That Phospholipid Oxidation Products and/or Platelet-Activating Factor Play an Important Role in Early Atherogenesis: In Vitro and In Vivo Inhibition by WEB 2086”, Circulation Research, 85: 311-318, 1999.
Tokumura et al. “Cardiovascular Effects of Lysophophatidic Acid and Its Structural Analogs in Rats”, The Journal of Pharmacology and Experimental Therapeutics, 219(1): 219-222, 1981.
Watson et al. “Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence In Vivo”.
Examination Report Dated Dec. 10, 2009 From the Intellectual Property Office of New Zealand Re.: Application No. 553147.
International Search Report Dated Mar. 13, 2009 From the International Searching Authority Re.: Application No. PCT/IL08/00013.
Response Dated Mar. 1, 2010 to Official Action of Dec. 1, 2009 From the US Patent and Trademark Office Re.: U.S. Appl. No. 11/650,973.
Response Dated Jan. 13, 2010 to Office Action of Nov. 13, 2009 From the State Intellectual Property Office of the People's Republic of China Re.: Application No. 200580029218.9.
Response Dated Jan. 28, 2010 to Official Action of Oct. 29, 2009 From the ROSPATENT, Federal State Office , Federal Institution of Industrial Property of the Federal Office of Intellectual Property, Patents and Trademarks of the Russian Federation Re.: Application No. 2007105097.
Translation of Notice of Reason for Rejection Dated Feb. 26, 2010 From the Japanese Patent Office Re.: Application No. 2007-519983.
Halperin Gideon
Kovalevski-Ishai Eti
Carr Deborah D
Vascular Biogenics Ltd.
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