OX40R binding agents

Details OX40R binding agents OX40R binding agents

2009-11-24

2010-12-28

Spector, Lorraine (Department: 1647)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023400, C435S252300, C435S320100, C435S069500, C424S192100, C424S193100, C424S195110

Reexamination Certificate

active

07858765

ABSTRACT:
The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with natural OX40L for blocking OX40R-mediated cell signaling in the prophylaxis and/or treatment of diseases related to activated T cells.

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