Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-04-27
2010-10-12
Krass, Frederick (Department: 1612)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07812046
ABSTRACT:
Methods are provided for treating or prophylactically preventing metabolic disorders in humans without causing, promoting, or aggravating fluid retention, peripheral edema, pulmonary edema, or congestive heart failure, by administration of a therapeutically effective amount of a compound sufficient to partially or fully activate peroxisome proliferator activated receptors (PPARs) and partially or fully inhibit, antagonize or block the activity of angiotensin II type 1 receptors. Metabolic disorders that can be treated or prevented include but are not limited to type 2 diabetes, the metabolic syndrome, prediabetes, and other insulin resistance syndromes. Compounds are provided that antagonize or block the angiotensin II type 1 (AT1) receptor, function as partial or full activators of peroxisome proliferator activated receptors (PPARs), can be used to treat or prevent diseases known to be treatable or preventable by PPAR activators and were not previously recognized to be therapeutic targets for angiotensin II receptor antagonists.
REFERENCES:
patent: 4156003 (1979-05-01), Metz et al.
patent: 5128356 (1992-07-01), Naka et al.
patent: 5162326 (1992-11-01), Naka et al.
patent: 5196444 (1993-03-01), Naka et al.
patent: 5243054 (1993-09-01), Naka et al.
patent: 5250554 (1993-10-01), Naka et al.
patent: 5284661 (1994-02-01), Morimoto et al.
patent: 5298497 (1994-03-01), Tschollar et al.
patent: 5328919 (1994-07-01), Naka et al.
patent: 5354766 (1994-10-01), Naka et al.
patent: 5389641 (1995-02-01), Naka et al.
patent: 5401764 (1995-03-01), Naka et al.
patent: 5463073 (1995-10-01), Takehiko et al.
patent: 5496835 (1996-03-01), Kubo et al.
patent: 5500427 (1996-03-01), Kubo et al.
patent: 5506245 (1996-04-01), Regnier et al.
patent: 5541229 (1996-07-01), Narr et al.
patent: 5565469 (1996-10-01), Mihm et al.
patent: 5583141 (1996-12-01), Naka et al.
patent: 5587393 (1996-12-01), Narr et al.
patent: 5591762 (1997-01-01), Hauel et al.
patent: 5594003 (1997-01-01), Hauel et al.
patent: 5602127 (1997-02-01), Hauel et al.
patent: 5614519 (1997-03-01), Hauel et al.
patent: 5639773 (1997-06-01), Kubo et al.
patent: 5661158 (1997-08-01), Ohtsuka et al.
patent: 5663186 (1997-09-01), Nelson et al.
patent: 5663187 (1997-09-01), Nelson et al.
patent: 5684029 (1997-11-01), Narr et al.
patent: 5693651 (1997-12-01), Nomura et al.
patent: 5703110 (1997-12-01), Naka et al.
patent: 5705517 (1998-01-01), Naka et al.
patent: 5736555 (1998-04-01), Naka et al.
patent: 5741803 (1998-04-01), Pool et al.
patent: 5801173 (1998-09-01), Lohray et al.
patent: 5811439 (1998-09-01), Ogawa et al.
patent: 5817075 (1998-10-01), Giungo
patent: 5824694 (1998-10-01), Kurtz et al.
patent: 5827865 (1998-10-01), Haigh et al.
patent: 5830909 (1998-11-01), Crandall
patent: 5834501 (1998-11-01), Fujita et al.
patent: 5843172 (1998-12-01), Yan
patent: 5843970 (1998-12-01), Pershadsingh et al.
patent: 5847008 (1998-12-01), Doebber et al.
patent: 5859051 (1999-01-01), Adams et al.
patent: 5864043 (1999-01-01), Narr et al.
patent: 5868728 (1999-02-01), Giungo et al.
patent: 5869495 (1999-02-01), Haigh et al.
patent: 5883111 (1999-03-01), Naka et al.
patent: 5885997 (1999-03-01), Lohray et al.
patent: 5886014 (1999-03-01), Fujita et al.
patent: 5889025 (1999-03-01), Lohray et al.
patent: 5889032 (1999-03-01), Lohray et al.
patent: 5902726 (1999-05-01), Kliewer et al.
patent: 5910592 (1999-06-01), Pool et al.
patent: 5919782 (1999-07-01), Lohray et al.
patent: 5925656 (1999-07-01), Kallam et al.
patent: 5932601 (1999-08-01), Sohda et al.
patent: 5939442 (1999-08-01), Evans et al.
patent: 5952356 (1999-09-01), Ikeda et al.
patent: 5952509 (1999-09-01), Saito et al.
patent: 5958942 (1999-09-01), Takatani et al.
patent: 5958961 (1999-09-01), Inada et al.
patent: 5962470 (1999-10-01), Fujita et al.
patent: 5962491 (1999-10-01), Naka et al.
patent: 5962500 (1999-10-01), Eide et al.
patent: 5965584 (1999-10-01), Ikeda et al.
patent: 5968589 (1999-10-01), Murakami
patent: 5972959 (1999-10-01), Yanagisawa et al.
patent: 5972970 (1999-10-01), Sohda et al.
patent: 5977365 (1999-11-01), Fujita et al.
patent: 5985884 (1999-11-01), Lohray et al.
patent: 5990139 (1999-11-01), Yano et al.
patent: 6004989 (1999-12-01), Naka et al.
patent: 6008237 (1999-12-01), Sahoo et al.
patent: 6011031 (2000-01-01), Lohray et al.
patent: 6011036 (2000-01-01), Lohray et al.
patent: RE36575 (2000-02-01), Meguro et al.
patent: 6020382 (2000-02-01), Doebber et al.
patent: 6022897 (2000-02-01), Evans et al.
patent: 6028088 (2000-02-01), Pershadsingh et al.
patent: 6087384 (2000-07-01), Matsui et al.
patent: 6087385 (2000-07-01), Pershadsingh et al.
patent: 6090836 (2000-07-01), Adams et al.
patent: 6090839 (2000-07-01), Adams et al.
patent: 6100252 (2000-08-01), Naka et al.
patent: 6100403 (2000-08-01), Saito et al.
patent: 6103742 (2000-08-01), Ikeda et al.
patent: 6113907 (2000-09-01), Khwaja et al.
patent: 6117893 (2000-09-01), Fujita et al.
patent: 6150371 (2000-11-01), Fujiwara et al.
patent: 6160000 (2000-12-01), Adams et al.
patent: 6200995 (2001-03-01), De la Brouse-Elwood et al.
patent: 6228874 (2001-05-01), Inada et al.
patent: 6232334 (2001-05-01), Naka et al.
patent: 6235311 (2001-05-01), Ullah et al.
patent: 6329415 (2001-12-01), Cirillo et al.
patent: 6333325 (2001-12-01), Cirillo et al.
patent: 6348481 (2002-02-01), Inada et al.
patent: 6353011 (2002-03-01), Pershadsingh et al.
patent: 6355808 (2002-03-01), Naka et al.
patent: 6355810 (2002-03-01), Griffin et al.
patent: 6358945 (2002-03-01), Breitfelder et al.
patent: 6369098 (2002-04-01), Pershadsingh et al.
patent: 6372773 (2002-04-01), Regan
patent: 6414002 (2002-07-01), Cheng et al.
patent: 6414008 (2002-07-01), Hauel et al.
patent: 6420405 (2002-07-01), Inada et al.
patent: 6432993 (2002-08-01), Fujita et al.
patent: 6432996 (2002-08-01), Tamura et al.
patent: 6451832 (2002-09-01), Ries et al.
patent: 6468996 (2002-10-01), Jeppesen et al.
patent: 6469039 (2002-10-01), Hauel et al.
patent: 6476023 (2002-11-01), Cirillo et al.
patent: 6479524 (2002-11-01), Priepke et al.
patent: 6486188 (2002-11-01), Pedersen et al.
patent: 6521747 (2003-02-01), Anastasio et al.
patent: 6689385 (2004-02-01), Richardson et al.
patent: 6897333 (2005-05-01), Guazzi
patent: 7232828 (2007-06-01), Pershadsingh
patent: 2002/0013334 (2002-01-01), Robl et al.
patent: 2002/0048798 (2002-04-01), Avery et al.
patent: 2002/0107236 (2002-08-01), Sahota
patent: 2004/0259925 (2004-12-01), Riedel et al.
patent: 2005/0004193 (2005-01-01), Riedel et al.
patent: 2006/0159747 (2006-07-01), Schumacher et al.
patent: 2007/0054949 (2007-03-01), Pershadsingh
patent: 2007/0160665 (2007-07-01), Brand et al.
patent: 2007/0185070 (2007-08-01), Pershadsingh
patent: 2008/0009536 (2008-01-01), Pershadsingh
patent: 0 454 511 (1991-10-01), None
patent: 1 356 815 (2003-10-01), None
patent: 1 536 785 (2005-06-01), None
patent: WO 93/01177 (1993-01-01), None
patent: WO-97/25042 (1997-07-01), None
patent: WO-97/28137 (1997-08-01), None
patent: WO 97/37688 (1997-10-01), None
patent: WO 97/37688 (1997-10-01), None
patent: WO-98/05331 (1998-02-01), None
patent: WO-98/05331 (1998-02-01), None
patent: WO-98/57941 (1998-12-01), None
patent: WO-99/62870 (1999-12-01), None
patent: WO-99/62871 (1999-12-01), None
patent: WO-99/62872 (1999-12-01), None
patent: WO-00/27832 (2000-05-01), None
patent: WO-00/27832 (2000-05-01), None
patent: WO-01/00603 (2001-01-01), None
patent: WO-01/12612 (2001-02-01), None
patent: WO 01/15673 (2001-03-01), None
patent: WO 01/15673 (2001-03-01), None
patent: WO-01/21602 (2001-03-01), None
patent: WO-01/34094 (2001-05-01), None
patent: WO-01/34094 (2001-05-01), None
patent: WO-01/76573 (2001-10-01), None
patent: WO-01/76573 (2001-10-01), None
patent: WO-01/76574 (2001-10-01), None
patent: WO-01/76574 (2001-10-01), None
patent: WO-01/82858 (2001-11-01), None
patent: WO-01/82858 (2001-11-01), None
patent: WO0215933 (2002-02-01), None
patent: WO-02/43807 (2002-06-01), None
patent: WO-02/43807 (2002-06-01), None
patent: WO-02/076177 (2002-10-01), None
patent: WO-02/076177 (2002-10-01), None
patent: WO-2004/014308 (2004-02-01), None
paten
Bethesda Pharmaceuticals, Inc.
Krass Frederick
Morrison & Foerster / LLP
Sznaidman Marcos
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