Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-13
2010-10-05
Chung, Susannah (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S272400, C548S152000, C548S263200
Reexamination Certificate
active
07807698
ABSTRACT:
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof:whereinG is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl, indazolyl;p is an integer ranging from 0 to 5;R1is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5; or corresponds to a group R5;R2is hydrogen or C1-4alkyl;R3is C1-4alkyl;R4is C1-4alkyl or C1-6cycloalkyl optionally substituted by 1 or 2 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl;R5is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such a group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl;processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3receptors, as antipsychotic agents, or to treat obsessive compulsive spectrum disorders or premature ejaculation.
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Arista Luca
Bonanomi Giorgio
Hamprecht Dieter
Micheli Fabrizio
Chung Susannah
Gimmi Edward R.
Glaxo Group Limited
Kanagy James M.
Kinzig Charles M.
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