Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
2007-02-05
2010-12-14
Davis, Ruth A (Department: 1651)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C424S422000
Reexamination Certificate
active
07850983
ABSTRACT:
Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living, core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.
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Sevrain Lionel C.
Verdier-Sevrain Sylvie Y.
Davis Ruth A
Fulbright & Jaworski L.L.P.
Spinalcyte, LLC
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