Pharmacological uses of azetidine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S210170, C514S210180, C514S210190, C514S210200, C514S210210, C548S950000, C548S152000, C548S202000, C548S217000, C548S364100, C548S518000, C544S060000, C544S111000, C544S242000, C544S359000, C546S139000, C546S150000, C546S176000, C546S268100

Reexamination Certificate

active

07741316

ABSTRACT:
A method of treating or preventing Alzheimer's disease, Parkinson's Disease and/or schizophrenia, this method comprising administering to a patient in need of such treatment a compound of formula:in which R, R3and R4are as defined in the specification.

REFERENCES:
patent: 4260606 (1981-04-01), Cale, Jr. et al.
patent: 5073646 (1991-12-01), Pinol et al.
patent: 6022868 (2000-02-01), Olesen et al.
patent: 6379666 (2002-04-01), Tobinick
patent: 2002/0081584 (2002-06-01), Blumenfeld et al.
DiMarzo et al. 2000, Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. FASEB J., vol. 14, pp. 1432-1438.
Poncelet et al. 1999, Blockade of cannabinoid (CB1) receptors by SR 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils. Psychopharmacology, vol. 144, pp. 144-150.
Arnone et al. 1997, Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology, vol. 132, pp. 104-106.
Barth F et al, The development of cannabinoid antagonists, Curr. Med. Chem., vol. 6(8), Aug. 1999, pp. 745-755.
Brotchie JM, CB1 cannabinoid receptor signalling in Parkinson's disease, Curr. Opin. Pharmacol., vol. 3(1), Feb. 2003, pp. 54-61.
Ruiu S et al, Synthesis and Characterization of NESS 0327: A Novel Putative Antagonist of the CB1 Cannabinoid Receptor, J. Pharmacol. Exp. ther., vol. 306(1), Jul. 2003, pp. 363-370.
Tzavara ET et al, The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortax: implications for therapeutic actions, J. Pharmacol., vol. 138(4), Feb. 2003, pp. 544-553.
W. E. Bachmann;Journal of the American Chemical Society; “The Relative Stability of Penta-Arylethanes I. The Preparation of Penta-Arylethanes”; May 1933; vol. 56; pp. 2135-2139.
A. L. Plasz et al.;Journal of the Chemical Society, Chemical Communications; “Photolytic Reduction of Phenyl Quinolin-3-yl Ketone to 3-Benzylquinoline”; 1972; pp. 527.
M. Hudlicky;ACS Monograph Series #186; “Oxidations in Organic Chemistry”; 1990; pp. 252-263.
G.A. Brine et al.;Journal of Heterocyclic Chemistry; “Carbon-13 Nuclear Magnetic Resonance Spectra of Fentanyl Analogs”; May-Jun. 1989; vol. 26; pp. 677-686.
D. Nagarathnam;Synthesis; “A Simple Synthesis of 2-Substituted Indoles”; Aug. 1992; pp. 743-745.
A. R. Katritzky et al.;Journal of Heterocyclic Chemistry; “Novel Syntheses of 1,3,3-Trinitroazetidine”; Mar.-Apr. 1994; vol. 31; pp. 271-275.
P. R. Dave;Journal of Organic Chemistry; “Acylative Dealkylation ofN-tert-Butyl-3-substituted Azetidines: Facile Access to [1.1.0] Azabicyclobutane, 3-Hydroxyazetidinium Hydrochloride, and 3-Azetidinones”; 1996; vol. 61; pp. 5453-5455.
M. Grisar et al.;Journal of Medicinal Chemistry; “Benzhydryl and Fluorenyl Lactamimides with Hypoglycemic, Diuretic, Blood Platelet Aggregation Inhibitory, and Antiinflammatory Activities”; 1973; vol. 16, No. 8; pp. 885-893.
N. G. Kundu et al.;Journal of the Chemical Society, Perkin Transactions 1; “Palladium-catalysed heteroannulation with acetylenic compounds: synthesis of benzofurnas”; 1997; pp. 2815-2820.
M. Moreno-Mañas et al.;European Journal of Medicinal Chemistry; “New imidazole anti-fungal agents derived from benzo[b]thiophene. Part II”; 1988; vol. 23; pp. 477-482.
Skinner et al.;Journal of Medicinal Chemistry; “Antiviral Agents. 1. Benzothiazol and Benzoxazole Analogs of 2-(α-Hydroxybenzyl)benzimidazole”; 1971; vol. 14, No. 6; pp. 546-549.
N. K. Harn;Tetrahedron Letters; “Acylation of Oxazoles by the Copper-Mediated Reaction of Oxazol-2-ylzinc Chloride Derivatives”; 1955; vol. 36, No. 52; pp. 9453-9456.
A. Medici et al.;Tetrahedron Letters; “Reactions of 2-Trimethylsilylthiazole with Acyl Chlorides and Aldehydes Synthesis of New Thiazol-2-YL Derivatives”; 1983; vol. 24, No. 28; pp. 2901-2904.
R. D. Riecke et al.;Journal of Organic Chemistry; “Direct Preparation of 3-Thienyl Organometallic Reagents: 3-Thienylzinc and 3-Thienylmagnesium Iodides and 3-Thienylmanganese Bromides and Their Coupling Reactions”; 1997; vol. 62, No. 20; pp. 6921-6927.
J. Knabe et al.;Archives of Pharmacology; “Synthese von 1-Acylisochinolinen über Reissert-Verbindungen”; 1973; vol. 306(9), pp. 648-658.
R. Consonni et al.;Journal of the Chemical Society—Perkin Transactions 1; “Diels-Alder reactions ofN-sulfonyl substituted aza-ortho-xylylenes generated from the corresponding 1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives”; 1996; pp. 1809-1814.
L. Brandsma et al.;Synthetic Communications; “A Large-Scale Procedure for the Preparation of 3-Bromothiophene From 2-Bromothiophene and Sodamide in Liquid Ammonia”; 1990, vol. 20(11); pp. 1697-1700.
M. Lemaire et al.;Synthetic Communications; “A Convenient Synthesis of 3-Fluorothiophene”; 1994; vol. 24(11); pp. 95-101.
H. Goda et al.;Synthesis; “Facile Synthesis of 5-Substituted 2-Acetylthiophenes”; 1992; vol. 9; pp. 849-851.
P. Baeuerle et al.;Journal of the Chemical Society-Perken Transactions 2; “Synthesis and Structural Characterization of Alkyl Oligothiophenes—The First Isomerically Pure Dialkylsexithiophene”; 1993; pp. 489-494.
P. Bouyssou et al.;Journal of Heterocyclic Chemistry; “Synthesis of 7- and 5,7-Substituted-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinolines: Convenient Precursors of Quinolone Antibacterial Agents”; 1992; vol. 29(4); pp. 895-898.
N. Suzuki et al.;Journal of the Chemical Society, Chemical Communications; “Synthetic Reactions in Polyethylene Glycol. Diazotization and Sandmeyer Reactions of Anilines in Polyethylene Glycol-Methylene Dichloride”; 1984; pp. 1523-1524.
S. Marburg et al.;Journal of Heterocyclic Chemistry; “A Short Efficient Synthesis of 4-Amino-2,3-dihydrobenzofuran”; 1980; vol. 17; pp. 1333-1335.
V. Percec et al.;Journal of Organic Chemistry; “Aryl Mesylates in Metal Catalyzed Homo- and Cross-Coupling Reactions. 4. Scope and Limitations of Aryl Mesylates in Nickel Catalyzed Cross-Coupling Reactions”; 1995; vol. 60(21); pp. 6895-6903.
J. F. Hansen et al.;Journal of Heterocyclic Chemistry; “Synthetic Studies Leading to DE-Ring Analogs of Camptothecin (1)”; 1973; vol. 10; pp. 711-714.
L. E. Hollister;Pharmacological Reviews; “Health Aspects of Cannabis”; 1986; vol. 38; pp. 1-20.
S. Renu;Progress in Drug Research; “Chemistry and Pharmacology of Cannabis”; 1991; vol. 36; pp. 71-115.
S. Consroe;Marijuana/Cannabinoids: Neurobiology and Neurophysiology(Eds. Murphy, L.; Barthe. A.); “Potential Role of Cannabinoids for Therapy of Neurological Disorders”; 1992; pp. 459-524.
J. E. Kuster; J. I. Stevenson et al.;Journal of Pharmacology and Experimental Therapeutics; “Aminoalkylindole Binding in Rat Cerebellum: Selective Displacement by Natural and Synthetic Cannabinoids”; 1993; vol. 264; pp. 1352-1363.
T. Hayashi et al;Journal of the American Chemicl Society; “Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium-(II): An Effective Catalyst for Cross-Coupling of Secondary and Primary Alkyl Grignard and Alkylzinc Reagents with Organic Halides”; 1984; vol. 106; pp. 158-163.
J. Wityak et al.;Bioorganic and Medicinal Chemistry Letters; “Synthesis and Antiplatelet Activity of DMP 757 Analogs”; 1995; vol. 5(18); pp. 2097-2100.
M. Desai; L. Stramiello;Tetrahedron Letters; “Polymer Bound EDC (P-EDC): A Convenient Reagent for Formation of an Amide Bond”; 1993; vol. 34(48); pp. 7685-7688.
G. Pandey; T. D. Bagul et al.;Journal of Organic Chemistry; “[3+2] Cycloaddition of Nonstabilized Azomethine Ylides. 7. Stereoselective Synthesis of Epibatidine and Analogues”; 1998; vol. 63; pp. 760-

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