Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-03-07
2010-06-22
Switzer, Juliet C (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200
Reexamination Certificate
active
07741029
ABSTRACT:
Based on the discovery of the nucleotide and amino acid differences which distinguish the Govaand Govballelic forms of the membrane glycoprotein CD109, and which comprise the biallelic Gov platelet alloantigen system, compositions and methods are provided for determining the Gov genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Gov alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenia. The two allelic forms of CD109 differ by a single amino acid. The Govaallelic form has Tyr at amino acid position 703 in the CD109 sequence. The Govballelic form has Ser at the same position. This amino acid difference is due to a single change, from A for the Govaallele to C for the Govballele, in the CD109 gene.
REFERENCES:
patent: 5474796 (1995-12-01), Brennan
patent: WO 91 03557 (1991-03-01), None
patent: WO 00/29448 (2000-05-01), None
patent: WO 02 070696 (2002-09-01), None
patent: WO 02 085942 (2002-10-01), None
Ouwehand and Navarrete. Molecular Haematology. Provan and Gribben (Eds) Blackwell Science 2000. Chapter 14, pp. 182-197.
Schuh et al. Blood, 2002, vol. 99, No. 5, pp. 1692-1698.
H.M. DeLisser. “Epitope Mapping.” Methods in Molecular Biology, vol. 96: Adhesion Protein Protocols, 1999, pp. 11-20.
C. Meier and J.W. Engels. “Peptide Nucleic Acids (PNAs)—Unusual Properties of Nonionic Oligonucleotide Analogues.” Angew. Chem. Int. Ed. Engl. 1992, vol. 31, No. 8, pp. 1008-1010.
U. Englisch and D.H. Gauss. “Chemically Modified Oligonucleotides as Probes and Inhibitors.” Angew. Chem. Int. Ed. Engl., vol. 30, No. 6, Jun. 1991, pp. 613-629.
F. Felici et al. “Peptide and protein display on the surface of filamentous bacteriophage.” Biotechnology Annual Review, vol. 1, 1995, pp. 149-183.
W. Gish and D.J. States. “Identification of protein coding regions by database similarity search.” Nature Genetics, vol. 3, Mar. 1993, pp. 266-272.
E.S. Kawasaki. “Amplification of RNA.” PCR Protocols: A guide to Methods and Applications, Academic Press Inc., 1990, pp. 21-27.
T.L. Madden et al. “Network BLAST Server Applications.” Methods in Enzymology, vol. 266 (1996) pp. 131-141.
B.A. Morgan and J.A. Gainor. “Approaches to the Discovery of Non-Peptide Ligands for Peptide Receptors and Peptidases.” Annual Reports in Medicinal Chemistry, Section VI—Topics in Chemistry and Drug Design, Chapter 26, 1989, pp. 243-252.
U. Reineke et al. “Antigen Sequence- and Library-Based Mapping of Linear and Discontinuous Protein-Protein-Interaction Sites by Spot Synthesis.” Current Topics in Microbiology and Immunology, 243 (1999), pp. 23-36.
A.C. Schuh et al. “Cell Surface Antigen CD109 Is a Novel Member of the a2 Macroglobulin/C3, C4, C5 Family of Thioester Containing Proteins.” Blood 98 (11):50b (2001).
R. Steen and T. Egeland. “CD34 Molecule Epitope Distribution on Cells of Haematopoietic Origin.” Leukemia and Lymphoma, 1998, vol. 30, pp. 23-30.
D.R. Sutherland and E.L. Yeo. “CDw109 Cluster report.” Leukocyte Typing V (Schlossman S. et al eds.), Oxford University Press, Oxford, pp. 1767-1769, 1995.
B. Westerlund-Wikstorm. “Peptide display on bacterial flagella: Principles and applications.” Int. J. Med. Microbiol., 290, pp. 223-230 (2000).
Database EMBL Online, Feb. 2, 2001. “Hydrophobic domain protein isolated from HT-1080 cells.” retrieved from EBI Database accession No. AAB12127.
J.F. Yu et al. “Comparison of the expression of CD109 and CD135 on CD34+ cells in human marrow, cord blood, and peripheral blood.” Blood, vol. 94, No. 10, Suppl. 1, Part 2, Nov. 1999, p. 136b.
Database EMBL ′Online, Feb 2, 2001. “Hydrophobic domain protein cDNA HP02837 isolated from HT-1080 cells.” Retrieved from EBI, Database accession No. AAA62010.
S.F. Altschul et al. “Basic Local Alignment Search Tool.” J. Mol. Biol. (1990) 215, pp. 403-410.
S.F. Altschul et al. “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.” Nucleic Acids Research, 1997, vol. 25, No. 17, pp. 3389-3402.
D. R. Burton. “Commentary Phage Display.” Immunotechnology 1, (1995), pp. 87-94.
R. Cortese et al. “Selection of biologically active peptides by phage display of random peptide libraries.” Current Opinion in Biotechnology, 1996, vol. 7, pp. 616-621.
J. M. Gershoni et al. “Combinatorial libraries, epitope structure and the prediction of protein conformation.” Immunology Today, Mar. 1997, vol. 18, Issue 3, pp. 108-110.
J. Goodchild. “Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties.” Bioconjugate Chemistry, May/Jun. 1990, vol. 1, No. 3, pp. 165-187.
E. Lesnik et al. “Oligodeoxynucleotides Containing 2′-O-Modified Adenosine: Synthesis and Effects on Stability of DNA:RNA Duplexes.” Biochemistry, 1993, vol. 32, No. 30, pp. 7832-7838.
J. Tseng-Law et al. “Identification of a peptide directed against the anti-CD34 antibody, 9C5, by phage display and its use in hematopoietic stem cell selection.” Experimental Hematology, 1999, vol. 27, 936-945.
J. Van de Water et al. “Detection of Molecular Determinants and Epitope Mapping Using Maldi-TOF Mass Spectrometry.” Clinical Immunology and Immunopathology, vol. 85, No. 3, Dec. 1997, pp. 229-235.
M. H. V. Van Regenmortel et al. “Measurement of antigen-antibody interactions with biosensors.” Journal of Molecular Recognition, 1998, vol. 11, pp. 163-167.
J. Zhang and T. L. Madden. PowerBLAST: A New Network BLAST Application for Interactive or Automated Sequence Analysis and Annotation. Genone Research, 1997, pp. 649-656.
J.O. Bordin et al. “Maternal immunization to Gov system alloantigens on human platelets.” Transfusion, vol. 37, No. 8, Aug. 1997, pp. 823-828.
R.W.A.M. Kuijpers et al. “NH2-Terminal Globular Domain of Human Platelet Glycoprotein Ib∝ Has a Methionine145/Threonine145Amino Acid Polymorphism, Which Is Associated with the HPA-2 (Ko) Alloantigens.” J. Clin. Invest., vol. 89, Feb. 1992, pp. 381-384.
T. Nakatani et al. “Functional Expression of Human Monoclonal Antibody Genes Directed Against Pseudomonal Exotoxin A in Mouse Myeloma Cells.” Bio/Technology, vol. 7, Aug. 1989, pp. 805-810.
P.J. Newman et al. “Enzymatic Amplification of Platelet-specific Messenger RNA Using the Polymerase Chain Reaction.” J. Clin. Invest., vol. 82, Aug. 1998, pp. 739-743.
P.J. Newman et al. “The Human Platelet Alloantigens, PlA1and PlA2, Are Associated with a Leucine33/Proline33Amino Acid Polymorphism in Membrane Glycoprotein IIIa, and Are Distinguishable by DNA Typing.” J. Clin. Invest., vol. 83, May 1989, pp. 1778-1781.
P.E. Nielsen et al. “Peptide nucleic acids (PNAs): Potential anti-sense and anti-gene agents.” Anti-Cancer Drug Design (1993), 8, pp. 53-63.
W. Ouwehand & C. Navarrete. “The molecular basis of blood cell alloantigens.” Molecular Haematology, Provan and Gribben (Eds), Blackwell Science (2000), Chapter 14, pp. 182-197.
D.R. Sutherland et al. “Identification of a Cell-Surface Antigen Associated With Activated T. Lymphoblasts and Activated Platelets.” Blood, vol. 77, No. 1 (Jan. 1, 1991), pp. 84-93.
R. Wang et al. “An Amino Acid Polymorphism within the RGD Binding Domain of Platelet Membrane Glycoprotein IIIa Is Responsible for the Formation of the Pena/PenbAlloantigen System.” J. Clin. Invest., vol. 90, Nov. 1992, pp. 2038-2043.
E.S. Ward et al. “Binding activities of a repertoire of single immunoglobulin variable domains secreted fromEscherichia coli.” Nature, vol. 341, Oct. 12, 1989, pp. 544-546.
J.W.
Ouwehand Willem
Schuh Andre
Ballard Spahr LLP
Switzer Juliet C
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