Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-01-03
2009-12-08
Kapushoc, Stephen (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100
Reexamination Certificate
active
07629123
ABSTRACT:
Mutations located within the gene encoding the homeobox transcription factor, ENGRAILED 2 (EN2), have now been identified as molecular markers associated with susceptibility for autism and related disorders. Thus, the present invention relates to compositions in the form of diagnostic kits, primers and target sequences, for use in methods for determining the predisposition, the onset or the presence of autism spectrum disorder in a mammal. Moreover, therapeutic methods for treating a person inflicted with, or predisposed to, an autism spectrum disorder based upon modulating the level or activity of EN2 are also provided.
REFERENCES:
Bartlett, et al. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Int J Dev Neurosci. Apr.-May 2005;23(2-3):221-34.
Hisanori, et al. Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. J Hum Genet. 2002;47(11):605-10.
Zhong, et al. No association between the EN2 gene and autistic disorder. J Med Genet. 2003(40):1-4.
Rebhan, et al.: GeneCards: encyclopedia for genes, proteins and diseases. 1997. GeneCard for [EN2] [Aug. 20, 2007] World Wide Web URL: http://www.genecards.org/cgi-bin/carddisp.pl?gene=EN2&search=EN2&ortholog=all&suff=txt#ort.
Geschwind, et al. Am. J. Hum. Genet. 2001; 69:463-6.
Liu, et al. Annu. Rev. Neurosci., 2001; 24:869-896.
Cheh, et al. Brain Research, 2006; 1116 :166-176.
Benayed, et al. Am J Hum Genet, 2005 77:851-868.
Gharani, et al. Molec Psycho, 2004; 9:474-484.
Hirschhorn et al. Genetics in Medicine. vol. 4, No. 2, pp. 45-61, Mar. 2002.
Nature Genetics, vol. 29, pp. 306-309, Nov. 2001.
Thisted R.A. ‘What is a P-vlaue?’ May 25, 1998, available online from http://www.stat.uchicago.edu/˜thisted, pp. 1-6.
Auranen et al., “A Genomewide Screen for Autism-Spectrum Disorders:Evidence for a Major Susceptibility Locus on Chromosome 3q25-27”, Am. J. Hum. Genet. 2002 71:777-790.
Hanks et al., “Rescue of theEn-1Mutant Phenotype by Replacement ofEn-1withEn-2”, Science 1995 269:679-682.
Kuemerle et al., “Pattern Deformities and Cell Loss inEngrailed-2Mutant Mice Suggest Two Separate Patterning Events during Cerebellar Development”, The Journal of Neuroscience 1997 17(20):7881-7889.
Liu et al., “Early Anterior/Posterior Patterning of the Midbrain and Cerebellum”, Annu. Rev. Neurosci. 2001 24:869-896.
Millen et al., “Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouseEngrailed-2mutants”, Development 1994 120: 695-706.
Millen et al., “A role forEn-2and other murine homologues ofDrosophilasegment polarity genes in regulating positional information in the developing cerebellum”, Development 1995 121:3935-3945.
Petit et al., “Association study with two markers of a human homeogene in infantile autism”, J. Med. Genet. 1995 32:269-274.
Zhong et al., “No association between the EN2 gene and autistic disorder”, J. Med. Genet 2003 40:1-4.
Alarcon et al., “Evidence for a Language Quantitative Trait Locus on Chromosome 7q in Multiplex Autism Families”, Am. J. Hum. Genet. 2002 70:60-71.
Liu et al., “A Genomewide Screen for Autism Susceptibility Loci”, Am J. Hum. Genet. 2001 69:327-240.
Logan et al., “Cloning and Sequence Comparison of the Mouse, Human, and Chicken engrailed Genes Reveal Potential Functional Domains and Regulatory Regions”, Developmental Genetics 1992 13:345-358.
Petit et al., “Association study with two markers of a human homeogene in infantile autism”, J. Med. Genet 1995 32:269-274.
Zhong et al., “No association between the EN2 gene and autistic disorder”, J. Med. Genet 2003 40:1-4.
Brzustowicz Linda
Gharani Neda
Millonig James H.
Kapushoc Stephen
Licata & Tyrrell P.C.
Rutgers The State University
University of Medicine and Dentistry of New Jersey
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