Optics: measuring and testing – By dispersed light spectroscopy – With raman type light scattering
Reexamination Certificate
2007-07-23
2009-06-02
Evans, F. L (Department: 2877)
Optics: measuring and testing
By dispersed light spectroscopy
With raman type light scattering
C356S036000
Reexamination Certificate
active
07542137
ABSTRACT:
The invention provides a system and method for automatic real-time monitoring for the presence of a pathogen in water using coherent anti-stokes Raman scattering (CARS) microscopy. Water sample trapped in a trapping medium is provided to a CARS imager. CARS images are provided to a processor for automatic analyzing for the presence of image artifacts having pre-determined features characteristic to the pathogen. If a match is found, a CARS spectrum is taken and compared to a stored library of reference pathogen-specific spectra for pathogen identification. The system enables automatic pathogen detection in flowing water in real time.
REFERENCES:
patent: 6950184 (2005-09-01), Stewart et al.
Grow et al, New Biochip Technology for Label-Free Detection of Pathogens and Their Toxins, Journal of Microbiological Methods, vol. 53, Issue 2, May 2003, pp. 221-233.
“Broadly tunable dual-wavelength light source for coherent anti-stokes raman scattering microscopy”, Ganikhanav et al, Optics Letters, vol. 31, No. 9, May 1, 2006.
“Optimization of coherent anti-stokes raman scattering microscopy using photonic crystal fiber”, Murugkar et al (to be published in Proceedings of SPIE 2007).
“A fast method for detecting Cryptosporidium parvum oocysts in real world samples”, Stewart et al, Advanced Biomedical and Clinical Diagnostic Systems III, SPIE, vol. 5692 (SPIE Bellingham, WA, 2005).
“Multi-focus coherent anti-stokes raman scattering microscopy”, Hashimoto et al, Microsc. Microanal 9 (Suppl 2), 2003, Copyright 2003 Microscopy Society of America.
Anis Hanan
Evans Conor
Murugkar Sangeeta
Xie Xiaoliang Sunney
Allen Dyer Doppelt Milbrath & Gilchrist, P.A.
Evans F. L
President and Fellows of Harvard College
University of Ottawa
LandOfFree
Pathogen detection using coherent anti-stokes Raman... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pathogen detection using coherent anti-stokes Raman..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pathogen detection using coherent anti-stokes Raman... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4142339