Therapeutic pyrazolo[3,4-b]pyridines and indazoles

Details Therapeutic pyrazolo[3,4-b]pyridines and indazoles Therapeutic pyrazolo[3,4-b]pyridines and indazoles

2006-06-02

2009-02-03

Anderson, Rebecca L (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S140000

Reexamination Certificate

active

07485636

ABSTRACT:
The present invention provides for compounds of Formula I:wherein R2, R3, R4, R5, R6, R7, X, and L have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of central nervous disorders and conditions including attention deficit hyperactivity disorder, neuropathic pain, urinary incontinence, anxiety, depression, and schizophrenia and fibromyalgia. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

REFERENCES:
patent: 3428634 (1969-02-01), Palazzo
patent: 3488353 (1970-01-01), Archer
patent: 3678059 (1972-07-01), Gschwend et al.
patent: 3681382 (1972-08-01), Gschwend
patent: 4474964 (1984-10-01), Ibuki et al.
patent: 4549023 (1985-10-01), Ibuki et al.
patent: 4585869 (1986-04-01), Ibuki et al.
patent: 4670447 (1987-06-01), Strupczewski
patent: 4710573 (1987-12-01), Strupczewski
patent: 4758668 (1988-07-01), Strupczewski
patent: 4775761 (1988-10-01), Strupczewski
patent: 4806649 (1989-02-01), Strupczewski
patent: 4853470 (1989-08-01), Strupczewski
patent: 4933460 (1990-06-01), Strupczewski
patent: 4954503 (1990-09-01), Strupczewski et al.
patent: 4957916 (1990-09-01), Kennis et al.
patent: 4999356 (1991-03-01), Strupczewski et al.
patent: 5015740 (1991-05-01), Kennis et al.
patent: 5077405 (1991-12-01), Strupczewski et al.
patent: 5134236 (1992-07-01), Strupczewski et al.
patent: 5348968 (1994-09-01), Lavielle et al.
patent: 5494908 (1996-02-01), O'Malley et al.
patent: 5538984 (1996-07-01), Villalobos et al.
patent: 5580982 (1996-12-01), O'Malley et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
patent: 5750542 (1998-05-01), Villalobos et al.
patent: 5756754 (1998-05-01), O'Malley et al.
patent: 5780475 (1998-07-01), Baker et al.
patent: 5854247 (1998-12-01), Baker et al.
patent: 5925766 (1999-07-01), O'Malley et al.
patent: 5965582 (1999-10-01), Lebaut et al.
patent: 5973156 (1999-10-01), Chambers et al.
patent: 5977116 (1999-11-01), Castro Pineiro et al.
patent: 5998415 (1999-12-01), Chambers et al.
patent: 6046203 (2000-04-01), O'Malley et al.
patent: 6054456 (2000-04-01), Ladduwahetty et al.
patent: 6166023 (2000-12-01), Schindler et al.
patent: 6166027 (2000-12-01), Straub et al.
patent: 6326382 (2001-12-01), Villalobos et al.
patent: 6329412 (2001-12-01), Goldstein et al.
patent: 6387940 (2002-05-01), Straub et al.
patent: 6391872 (2002-05-01), Marfat
patent: 6410740 (2002-06-01), Straub et al.
patent: 6414009 (2002-07-01), Straub et al.
patent: 6451805 (2002-09-01), Straub et al.
patent: 6462068 (2002-10-01), Straub et al.
patent: 6465467 (2002-10-01), Nilsson et al.
patent: 6498255 (2002-12-01), Villalobos et al.
patent: 6541484 (2003-04-01), Collins et al.
patent: 6552192 (2003-04-01), Hanus et al.
patent: 6743798 (2004-06-01), Straub et al.
patent: 2002/0028834 (2002-03-01), Villalobos et al.
patent: 2002/0052373 (2002-05-01), Zom et al.
patent: 2002/0198213 (2002-12-01), Zhou et al.
patent: 2003/0073849 (2003-04-01), Mattson et al.
patent: 2003/0092694 (2003-05-01), Nilsson et al.
patent: 2003/0176421 (2003-09-01), Watson et al.
patent: 2003/0191086 (2003-10-01), Hanus et al.
patent: 2004/0063713 (2004-04-01), Cowart et al.
patent: 2004/0186148 (2004-09-01), Shankar et al.
patent: 2004/0224945 (2004-11-01), Straub et al.
patent: 2004/0236101 (2004-11-01), Makriyannis et al.
patent: 2004/0242554 (2004-12-01), Nilsson et al.
patent: 2006/0019967 (2006-01-01), Wu et al.
patent: 3338903 (1985-05-01), None
patent: 0 135 781 (1989-10-01), None
patent: 0 562 832 (1993-03-01), None
patent: 1 040 829 (1999-12-01), None
patent: 2 034 495 (1970-01-01), None
patent: 58-159469 (1983-09-01), None
patent: 3-223265 (1991-10-01), None
patent: 11-279156 (1999-10-01), None
patent: 2003-146879 (2003-05-01), None
patent: 2003-146973 (2003-05-01), None
patent: WO 98/01428 (1998-01-01), None
patent: WO 99/58503 (1999-11-01), None
patent: WO 00/06559 (2000-02-01), None
patent: WO 00/27394 (2000-05-01), None
patent: WO 00/43394 (2000-07-01), None
patent: WO 00/76984 (2000-12-01), None
patent: WO 01/44244 (2001-06-01), None
patent: WO 01/57024 (2001-08-01), None
patent: WO 01/70701 (2001-09-01), None
patent: WO 01/70702 (2001-09-01), None
patent: WO 03/076408 (2003-09-01), None
patent: WO 03/101994 (2003-12-01), None
patent: WO 2004/085385 (2004-10-01), None
FDA mulls drug to slow late-stage Alzheimer's [online], [retrieved on Sep. 23, 2003]. Retrieved from the internet, URL <http://www.cnn.com/2003/HEALTH/conditions/09/24/alzheimers.drug.ap/index.html>.
Cecil Textbook of Medicine, 20th edition (1996), vol. 2, pp. 1992-1996.
Baiocchi et al., “Synthesis, Properties, and Reactions of 1H-Indazol-3-ols and 1,2-Dihydro-3H-indazol-3-ones”, Synthesis, Sep. 1976, pp. 633-648.
Palazzo et al., “Synthesis and Pharmacological Properties of 1-Substituted 3-Dimethylaminoalkoxy-1H-Indazoles”, J. Med. Chem., Jan. 1986, vol. 9, pp. 38-41.
Selwood et al., “Synthesis and Biological Evaluation of Novel Pyrazoles and Indazoles as Activators of the Nitric Oxide Receptor, Soluble Guanylate Cyclase”, J. Med. Chem., 2001, vol. 44, pp. 78-93.
Sluka, “Stimulation of Deep Somatic Tissue with Capsaicin Produces Long-Lasting Mechanical Allodynia and Heat Hypoalgesia that Depends on Early Activation of the cAMP Pathway”, J. Neurosci., Jul. 2002, vol. 22, No. 13, pp. 5687-5693.
PCT International Search Report for PCT/IB2005/003549 mailed Oct. 19, 2006.

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