Immunoglobulin a binding protein

Details Immunoglobulin a binding protein Immunoglobulin a binding protein

1994-10-03

1996-09-17

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530402, 435 691, C07K 14315, C07K 1700

Patent

active

055569447

ABSTRACT:
The subject invention concerns a novel polynucleotide sequence cloned from emm2.2 gene of a Group A streptococcus, Type II strain which codes for an IgA-binding protein,ML2.2. The subject invention further concerns the novel IgA-binding protein. A process for producing the protein is given. The invention also concerns the protein in an immunoadsorbent and as a tracer for use in measuring and purifying IgA. Kits are given comprising the immunoadsorbent and the tracer form of the protein.

REFERENCES:
patent: 4757134 (1988-07-01), Blake et al.
patent: 5210183 (1993-05-01), Lindahl et al.
Lehninger, A. L. (1975) Biochemistry, 2nd Ed., New York: Worth; p. 73.
Lancefield, R. C. (1962) "Current Knowledge of Type-Specific M Antigens of Group B Streptococci" J. Immunol. 89:307-313.
Frithz, E., L. O. Heden, G. Lindahl (1989) "Extensive sequence homology between IgA receptor and M proteins in Streptococcus pyogenes" Molecular Microbiology 3(8):1111-1119.
Bessen, D., K. F. Jones, V. A. Fischetti (1989) "Evidence for Two Distinct Classes of Streptococcal M Protein and Their Relationship to Rheumatic Fever" J. Exp. Med. 169:269-283.
Bessen, D. E., V. A. Fischetti (1990) "Differentiation Between Two Biologically Distinct Classes of Group A. Streptococci by Limited Substitutions of Amino Acids within the Shared Region of M Protein-like Molecules" J. Exp. Med. 172:1757-1764.
Bessen, D., V. A. Fischetti (1990) "A Human IgG Receptor of Group A Streptococci Is Associated with Tissue Site of Infection and Streptococcal Class" The Journal of Infectious Diseases 161:747-754.
Khandke, K. M. et al. (1986) "Complete Amino Acid Sequence of Streptococcal PepM49 Protein, A Nephritis-associated Serotype" The Journal of Biological Chemistry 263(11):5075-5081.
Bessen, D. E., V. A., Fischetti (1992) "Nucleotide Sequences of Two Adjacent M or M-Like Protein genes of Group A Streptococci: Different RNA Transcript Levels and Identification of a Unique Immunoglobulin A-Binding Protein" Infection and Immunity 60(1):124-135.
Haanes, E. J., P. P. Clearly (1989) "Identification of a Divergent M Protein Gene and an M Protein-Related Gene Family in Streptococcus pyogenes Serotype 49" Journal of Bacteriology 171(12):6397-6408.
Jeppson, H., E. Frinthz, L.-O. Heden (1992) "Duplication of a DNA sequence homologous to genes for immunoglobulin receptors and M proteins in Streptococcus pyogenes"FEMS Microbiology Letters 92:139-146.

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