TNF-α production inhibitors

Details TNF-α production inhibitors TNF-α production inhibitors

2006-06-07

2009-02-17

Aulakh, Charanjit S (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S332000, C546S329000

Reexamination Certificate

active

07491739

ABSTRACT:
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities,wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5and R6are hydrogen, alkyl, alkenyl, adamantyl or the like, R3is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.

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