Method for treating glaucoma by the topical administration of se

Details Method for treating glaucoma by the topical administration of se Method for treating glaucoma by the topical administration of se

1981-06-23

1984-06-19

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 3124

Patent

active

044553170

ABSTRACT:
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula: ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl, or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.

REFERENCES:
patent: 3663607 (1972-05-01), Barrett et al.
patent: 3740444 (1973-06-01), Koppe et al.
patent: 3793365 (1974-02-01), Winter et al.
patent: 3825583 (1974-07-01), Hussain et al.
patent: 3839584 (1974-10-01), Hussain et al.
patent: 3868460 (1975-02-01), Koppe et al.
patent: 3925446 (1975-12-01), Koppe et al.
patent: 4080471 (1978-03-01), Carlsson et al.
patent: 4127674 (1978-11-01), Leopold
patent: 4146638 (1979-03-01), Renth et al.
patent: 4191765 (1980-03-01), Fritsch et al.
patent: 4195085 (1980-03-01), Stone
The Lancet, Nov. 10, 1979, p. 1028-Ahmad.
J. Am. Med. Assoc., 243, (11), 1131, (1980)-Kohn.
New Eng. J of Med., Mar. 8, 1979, p. 566-Britman.
Drug Therapy, Jul. 1979, pp. 93-94.
Inpharma, Jun. 7, 1980, p. 7-Guzman.
Inpharma, Jul. 12, 1980, pp. 7-8, Kim & Smith and Sando.
Physicians' Desk Reference, Charles E. Baker, Jr., 35th Edition, 1232-1234, (1981).
W. P. Boger, Drugs, 18, 25-32, (1979).
L. Bonomi et al., Glaucoma, Eds. R. Pitts Corck and A. D. S. Caldwell, Academic Press, New York, pp. 99-105, (1980).
Demmler, Forshr. Med. 98, Jg, (1980), Nr. 23, pp. 880-885.
Heel et al., Drugs, 17, 38-55, (1979).
Krieglstein et al., Albrecht v. Graefes Arch. klin. epx. Opthal., 202, 81-86, (1977).
P. Vareilles et al., Investigative Ophthalmology and Visual Science, vol. 16/11, 987, (1977).
T. Zimmerman, Drug Therapy, Jul. 1979, pp. 87-89.
T. J. Zimmerman and W. P. Boger, Surv. Ophthalmol.

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