Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2003-09-30
2009-08-18
McIntosh, III, Traviss C (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S025000, C514S866000, C536S004100, C536S018100
Reexamination Certificate
active
07576063
ABSTRACT:
The present invention provides pyrazole derivatives represented by the general formula:wherein R1represents H, an optionally substituted C1-6alkyl group etc.; one of Q and T represents a group selected from the following groups:and the other represents —(CH2)n—Ar wherein Ar represents an optionally substituted C6-10aryl group or an optionally substituted C1-9heteroaryl group; and n represents an integral number from 0 to 2, an optionally substituted C1-6alkoxyl group, an optionally substituted amino group, an optionally substituted C2-9heterocycloalkyl group or an optionally substituted heterocycle-fused phenyl group; R represents an optionally substituted C3-8cycloalkyl group, an optionally substituted C6-10aryl group etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human 1,5-anhydroglucitol/fructose/mannose transporter and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose or a disease associated with hyperglycemia (e.g., diabetic complications, diabetes, etc.), and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
REFERENCES:
patent: 4410525 (1983-10-01), Jarreau et al.
patent: 4526895 (1985-07-01), Jarreau et al.
patent: 6414126 (2002-07-01), Ellsworth et al.
patent: 6455525 (2002-09-01), Singh et al.
patent: 6515117 (2003-02-01), Ellsworth et al.
patent: 6815428 (2004-11-01), Ohsumi et al.
patent: 6972283 (2005-12-01), Fujikura et al.
patent: 7084123 (2006-08-01), Fujikura et al.
patent: 7087579 (2006-08-01), Nishimura et al.
patent: 7294618 (2007-11-01), Fushimi et al.
patent: 2003/0087843 (2003-05-01), Washburn
patent: 2003/0137903 (2003-07-01), Hiranuma et al.
patent: 2003/0162775 (2003-08-01), Singh et al.
patent: 2004/0053397 (2004-03-01), Iwamoto et al.
patent: 2004/0110936 (2004-06-01), Ohsumi et al.
patent: 2004/0116357 (2004-06-01), Fushimi et al.
patent: 2004/0132669 (2004-07-01), Nishimura et al.
patent: 2004/0176308 (2004-09-01), Shiohara et al.
patent: 0 076 756 (1983-04-01), None
patent: 0 099 815 (1984-02-01), None
patent: 1213296 (2002-06-01), None
patent: 1338603 (2003-08-01), None
patent: 1354888 (2003-10-01), None
patent: 2529786 (1984-01-01), None
patent: 2003-012686 (2003-01-01), None
patent: WO 01/16147 (2001-03-01), None
patent: WO 01/27128 (2001-04-01), None
patent: 01/32653 (2001-05-01), None
patent: WO 02/36602 (2002-05-01), None
patent: WO 02/053573 (2002-07-01), None
patent: WO 02/053738 (2002-07-01), None
patent: WO 02/068439 (2002-09-01), None
patent: WO 02/068440 (2002-09-01), None
patent: WO 02/088157 (2002-11-01), None
patent: WO 02/098893 (2002-12-01), None
patent: WO 03/020737 (2003-03-01), None
Yamanouchi, T. et al., Common reabsorption system of 1, 5-anhydro-D-glucitol, fructose, and mannose in rat renaltubule., Biochim. Biophys.Acta., 1996, 1291, pp. 89 to 95.
Kees, Kenneth L. et al., Studies on New Acidic Azoles as Glucose-Lowering Agents in Obese, Diabetic db/db Mice, Journal of Medicinal Chemistry, vol. 38, No. 4, pp. 617-628 (1995).
Ila Sircar, et al.; Cardiotonic Agents. 6. Synthesis and Inotropic Activity of 2,4-Dihydro-5-[4-(1H-imidazol-l-yl)phenyl]-3H-pyrazol-3-ones: Ring-Contracted Analogues of Imazodan (CI-914), Journal of Medicinal Chemistry, vol. 30, No. 10, pp. 1724-1728 (1987).
Sakakibara H. et al., Reactions of 2,3-Dimethylindole and Tetrahydrocarbozole with N-Bromosuccimide, Tetrahedron, vol. 22, No. 8, pp. 2475-2479 (1966).
Leemann H. G. et al.L“20. Uber die Ermittlung der Struktur eines bei der Herstellung von 1-[N-Methylpiperidyl-(4′)]-4-benzyl-5-phenyl-pyrazol-3-on” Helvetica Chimica Acta, vol. 45, pp. 177-179 (1962).
Veibel, Stig et al., Pyrazole Studies, VIII Oxidation of 4-Alkylsubstituted Pyrazol-5-ones with Tertiary Butylhydroperoxide, Acta Chimica Scandinavica, vol. 8, pp. 1383-1388 (1954).
Gagnon, Paul E. et al., Study of 4-Mono- and 4,4-Disubstituted-3-Imino-2-Benzoly-5-Pyrazolones, Canadian Journal of Chemistry, vol. 30, pp. 52-61 (1952).
Gagnon, Paul E. et al., Synthesis and Ultraviolet Absorption of Some Pyrazolones, Canadian Journal of Chemistry, vol. 29, pp. 843-847 (1951).
Gagnon, Paul E. et al, Contribution to the Study of 4-Monosubstituted-3-Amino-5-Pyrazolones, Canadian Journal of Chemistry, vol. 29, pp. 328-332 (1951).
Gagnon, Paul E. et al., The Synthesis and Ultraviolet Spectra of Some Pyrazolones, Canadian Journal of Chemistry, vol. 29, pp. 182-191 (1951).
Fujikura Hideki
Isaji Masayuki
Kikuchi Norihiko
Tazawa Shigeki
Yamato Tokuhisa
Kissei Pharmaceutical Co. Ltd.
McIntosh, III Traviss C
Sughrue & Mion, PLLC
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