Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-10-29
2009-02-03
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S259500, C544S183000, C544S281000
Reexamination Certificate
active
07485640
ABSTRACT:
The present invention discloses a compound of formula I, or a pharmaceutically acceptable salt thereof: (I) wherein —U—V— represents —CH═CH—, or —CH2—CH2—, —N═CH— or —CH═N—; X1represents hydrogen, halogen, C1-6alkyl, trifluoromethyl or C1-6alkoxy; X2represents hydrogen or halogen; Y represents a chemical bond, an oxygen atom, or a —NH— or —OCH2— linkage; Z represents an optionally substituted aryl or heteroaryl group; R1represents hydrocarbon, a heterocyclic group, trifluoromethyl, —SO2Ra, —SO2NRaRb, —CORa, —CO2Raor —CONRaRb; and Raand Rbindependently represent hydrogen, hydrocarbon or a heterocyclic group; pharmaceutical compositions comprising it; its use in methods of treatment; use of it in the manufacture of a medicament for treating and/or preventing anxiety; convulsions or a cognitive disorder; and methods of treatment using it.
REFERENCES:
patent: 4329970 (1994-06-01), None
patent: WO 02 10170 (2002-02-01), None
patent: WO 02 38568 (2002-05-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Carling William Robert
Castro Pineiro Jose Luis
Goodacre Simon Charles
Hallett David James
Street Leslie Joseph
Krovatin William
Merck Sharp & Dohme Limited
Murray Jeffrey H
Thies J. Eric
Wilson James O
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