Supramolecular complexes as photoactivated DNA cleavage agents

Details Supramolecular complexes as photoactivated DNA cleavage agents Supramolecular complexes as photoactivated DNA cleavage agents

2005-07-20

2009-11-03

Marschel, Ardin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S184000

Reexamination Certificate

active

07612057

ABSTRACT:
The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.

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J McCaughan Jr. “Photodynamic Therapy: A Review”. Drugs and Aging, 1999; 15(1):49-68.
Swavey et al. “Visible Light Induced Photocleavage of DNA by a Mixed-Metal Supramolecular Complex: [{(bpy)2Ru(dpp)}2RhCl2]5+”. Inorganic Chemistry, 2002; 41:6196-6198.
Lee Goldman, et al. (Editors): Cecil Textbook of Medicine; 21st Edition. W. B. Saunders Company, 2000. p. 1060-1074.

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