Substituted hydantoins

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S389000

Reexamination Certificate

active

07612212

ABSTRACT:
The present invention relates to compounds of the formulamethods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.

REFERENCES:
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patent: WO 99/05117 (1999-02-01), None
patent: WO-99/05117 (1999-02-01), None
patent: WO 01/83478 (2001-11-01), None
patent: WO 2004/024715 (2004-03-01), None
patent: WO 2006/018188 (2006-02-01), None
patent: WO 2006/029862 (2006-03-01), None
CAS Abstract 1931:37702, Locquin et al. Bulletin de la Societe Chimique de France (1931), vol. 49, pp. 595-600.
CAS Abstract 1931:37701, Policard, Andrew. Bulletin de la Societe Chimique de France (1931), vol. 4, pp. 607-612.
Hyun et al., J. Liq. Chrom. Rel. Technol., 25, pp. 573-588 (2002).
Böhme et al., J. Med. Chem., 23, pp. 405-412 (1980).
Salituro et al., J. Am. Chem. Soc., 112, pp. 760-770 (1990).
Shimizu et al., J. Chem. Soc. Chem. Commun., 867-868 (1986).
Chemical Abstract Service XP002428310.

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