Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-10-24
2009-10-13
Lundgren, Jeffrey S. (Department: 1639)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C506S016000, C506S013000, C506S023000, C506S007000
Reexamination Certificate
active
07601823
ABSTRACT:
The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
Djordjevic, Biomolecular Engineering 24:179-189 (2007).
Shamah et al., Accounts of Chemical Research 41(1):130-138 (2008).
Huang et al., Biochemistry 46:12648-12655 (2007).
Huang Zhen
Lis John T.
Niu Li
Shi Hua
Cornell University
Dias, Esq. Kathy Smith
Heslin Rothenberg Farley & & Mesiti P.C.
Lundgren Jeffrey S.
The Research Foundation of State University of New York
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