Prostaglandin receptor EP1

Details Prostaglandin receptor EP1 Prostaglandin receptor EP1

2006-09-05

2009-10-27

Gamett, Daniel C (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007210, C435S007100, C435S069100

Reexamination Certificate

active

07608411

ABSTRACT:
(1) A novel polypeptide prostaglandin E receptor, (2) a cDNA encoding the polypeptide and a fragment selectively hybridized to the sequence of the cDNA, (3) a replication or expression vector carrying the DNA, (4) a host cell transformed with the replication or the expression vector, (5) a method for producing the polypeptide which comprises culturing the host cells, (6) a monoclonal or polyclonal antibody against the polypeptide, (7) a pharmaceutical composition containing the polypeptide or the antibody, in association with pharmaceutically acceptable excipient and/or antibody, (8) a screening method for a compound having agonistic or antagonistic activity against EP1, comprising using the polypeptide or the host cell.The polypeptide of the present invention can be used for treating diseases, which is caused by over production of PGE2, such as pain, fever and pollakiuria.

REFERENCES:
patent: 5985597 (1999-11-01), Ford-Hutchinson et al.
patent: WO 94/28125 (1994-12-01), None
patent: WO 00/29614 (2000-05-01), None
Abramowitz, Biochem. Biophys. Acta. Jan. 17, 2000;1483(2):285-293.

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