Long acting beta-2-agonists and their use as medicaments

Details Long acting beta-2-agonists and their use as medicaments Long acting beta-2-agonists and their use as medicaments

2008-04-11

2009-12-15

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S266210, C514S312000

Reexamination Certificate

active

07632834

ABSTRACT:
A compound of formula 1′″wherein:V is —CH2—, —NH—, or —O—;Raand Rbare each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, orRaand Rbtogether are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen;R1and R1′are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, orR1and R1′together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen;R2, R2′, R2″, and R2′″are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; andn is 0, 1, or 2,or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.

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